GNA14

GNA14
Identifiers
Aliases	GNA14, G protein subunit alpha 14, HG1I
External IDs	OMIM: 604397 MGI: 95769 HomoloGene: 68386 GeneCards: GNA14
Gene location (Human)
Chr.	Chromosome 9 (human)
End	77,648,322 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	16,588,184 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; bronchial epithelial cell; ; smooth muscle tissue; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; myometrium; ; upper lobe of left lung; ; right lung; ; rectum; ; sperm;
	Top expressed in
	secondary oocyte; ; facial motor nucleus; ; left colon; ; stria vascularis; ; adrenal gland; ; rectum; ; primitive streak; ; Hindgut; ; anterior horn of spinal cord; ; cumulus cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl nucleotide binding; nucleotide binding; GTP binding; protein binding; metal ion binding; G protein-coupled receptor binding; GTPase activity; signal transducer activity; G-protein beta/gamma-subunit complex binding;
Cellular component	plasma membrane; extracellular exosome; heterotrimeric G-protein complex;
Biological process	platelet activation; phospholipase C-activating dopamine receptor signaling pathway; signal transduction; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9630
	14675
	ENSG00000156049
	ENSMUSG00000024697
	O95837
	P30677
	NM_004297
	NM_008137
	NP_004288
	NP_032163
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-14 is a protein that in humans is encoded by the GNA14 gene.^[5]^[6]^[7] G₁₄α is a member of the Gq alpha subunit family, and functions as a constituent of a heterotrimeric G protein in cell signal transduction.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156049 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024697 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
^ "Entrez Gene: GNA14 G protein subunit alpha 14 [ Homo sapiens (human) ]". Retrieved 2019-07-25.
^ GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-14; GNA14 at OMIM. Retrieved JULY 25, 2019.