Frederic Bartter

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Frederic Crosby Bartter
BornSeptember 10, 1914 (1914-09-10)
Manila, Philippines
DiedMay 5, 1983 (1983-05-06) (aged 68)
Occupationendocrinologist
SpouseJane Lillard

Frederic Crosby Bartter (September 10, 1914 – May 5, 1983) was an American endocrinologist best known for his work on hormones affecting the kidney and his discovery of syndrome of inappropriate antidiuretic hormone[1] and Bartter syndrome.[2] He had a separate interest in mushroom poisoning.[3]

Early life

He was born to an English Anglican minister and his American wife in Manila, Philippines, and grew up in the mountain village of Baguio. At the age of 13 he was sent, together with his brother, to attend the Lenox School until 1930. After teaching in the Philippines for a year, he enrolled at Harvard where he obtained a BA in 1935. After a year at Harvard School of Public Health he entered Harvard Medical School, graduating there in 1940. Internships took place at Roosevelt Hospital in New York City in 1941 and 1942. Army service led to academic work on blood products and onchocerciasis (river blindness, a tropical disease).[3]

Boston

He became a research fellow to Fuller Albright at Massachusetts General Hospital in 1946, and joined the clinical staff in 1950. Albright influenced Bartter significantly in several ways: research was mainly conducted on patients, who were observed very closely for long periods of time, and his interests encompassed many fields. Particular interests were calcium metabolism, the hypothalamic-pituitary-adrenal axis, blood volume and electrolyte physiology, and the actions of sex steroids. Significant observations were made in congenital adrenal hyperplasia.[3]

Bethesda

From 1951 to 1978 Bartter served as Chief of the National Institutes of Health Endocrine-Hypertension Branch.[4] Much of his work here was on aldosterone and its effects on the cardiovascular system. He collaborated with numerous researchers, including Grant Liddle (eponymised in Liddle's syndrome). Investigations in 1957 led to the recognition of SIADH,[1][5] and his work on aldosterone and the kidney handling of electrolytes led to his description in 1963 of the syndrome that would later bear his name - Bartter syndrome.[2][3]

Texas

In 1978 he moved, this time to the University of Texas Health Science Center at San Antonio. Here he continued his work on hypertension (high blood pressure) started at Bethesda, and his own hypertension was discovered during the research.[3]

He was elected to the National Academy of Sciences in 1979, already having received honours by the American Society for Clinical Investigation, the Endocrine Society, and numerous other bodies. He collapsed suddenly due to a cerebral hemorrhage at an NAS conference, and died soon afterwards. He was married to Jane Lillard and left three children, two sons and a daughter.[3]

Since 1986, the American Society for Bone and Mineral Research has given the Frederic C. Bartter Award for outstanding clinical investigation.[4]

References

  1. ^ a b Schwartz WB, Bennett W, Curelop S, Bartter FC (1957). "A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone". Am. J. Med. 23 (4): 529–42. doi:10.1016/0002-9343(57)90224-3. PMID 13469824. reproduced in Schwartz WB, Bennett W, Curelop S, Bartter FC (1 December 2001). "A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. 1957". J. Am. Soc. Nephrol. 12 (12): 2860–70. doi:10.1681/ASN.V12122860. PMID 11729259.
  2. ^ a b Bartter FC, Pronove P, Gill JR Jr, MacCardle RC (1962). "Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome". Am J Med. 33 (6): 811–28. doi:10.1016/0002-9343(62)90214-0. PMID 13969763. Reproduced in Bartter FC, Pronove P, Gill JR, MacCardle RC (1998). "Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. 1962". J. Am. Soc. Nephrol. 9 (3): 516–28. doi:10.1681/ASN.V93516. PMID 9513916.
  3. ^ a b c d e f Jean D. Wilson; Catherine S. Delea (1990). "Frederic C. Bartter" (PDF). Biographical Memoirs. Washington, D.C: National Academy Press. pp. 2–25. ISBN 0-309-04198-8.
  4. ^ a b American Society of Bone and Mineral Research Annual Bartter Awards
  5. ^ Bartter FC, Schwartz WB (1967). "The syndrome of inappropriate secretion of antidiuretic hormone". Am. J. Med. 42 (5): 790–806. doi:10.1016/0002-9343(67)90096-4. PMID 5337379. S2CID 1666659.
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