Formyl-CoA hydrolase

The enzyme formyl-CoA hydrolase (EC 3.1.2.10) catalyzes the reaction

formyl-CoA + H₂O

\rightleftharpoons

CoA + formate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is formyl-CoA hydrolase. This enzyme is also called formyl coenzyme A hydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

References

Sly WS, Stadtman ER (August 1963). "Formate metabolism. I. Formyl coenzyme A, an intermediate in the formate-dependent decomposition of acetyl phosphate in Clostridium kluyveri". The Journal of Biological Chemistry. 238: 2632–8. PMID 14063284.

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v t e Thioesterases (EC 3.1.2)
Acetyl-CoA thioesterases
Acyl-CoA thioesterases	ACOT1 ACOT2 ACOT4 ACOT6 ACOT7 ACOT8 ACOT9 ACOT11 ACOT12 ACOT13
Formyl-CoA thioesterases
Palmitoyl protein thioesterases	PPT1 PPT2
Succinyl-CoA thioesterases
Ubiquitin C-terminal hydrolases	UCHL1 UCHL3 UCHL5

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)