Fluorescein (medical use)
Fluorescein drops being put in the eye before examination
|Trade names||Fluorescite, AK-Fluor, BioGlo, others|
|Drug class||Diagnostic agent|
|Eye drops, intravenous, by mouth|
|Defined daily dose||not established|
|Chemical and physical data|
|Molar mass||332.311 g·mol−1|
|3D model (JSmol)|
Fluorescein is used to help in the diagnosis of a number of eye problems. When applied as a drop or within a strip of paper to the surface of the eye it is used to help detect eye injuries such as foreign bodies and corneal abrasions. When given by mouth or injection into a vein it is used to help evaluate the blood vessels in the back of the eye during fluorescein angiography.
When applied to the surface of the eye side effects may include a brief period of blurry vision and discoloration of contact lenses of the soft type. When used by mouth or injection side effects may include headache, nausea, and a change to the color of the skin for a brief period of time. Allergic reactions may rarely occur. Fluorescein is a dye which is taken up by damaged cornea such that the area appears green under cobalt blue light. There is also a version that comes premixed with lidocaine.
Fluorescein was first made in 1871. It is on the World Health Organization's List of Essential Medicines. The wholesale cost in the developing world is about US$12.25 per 5 ml bottle. In the United Kingdom a single dose costs the NHS about 0.43 pounds. It is also not very expensive in the United States.
It is also sometimes administered to pets in multi-pet environments to determine which pet needs behavioral modification.
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