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Summary
DescriptionSARS-CoV MERS-CoV genome organization and S-protein domains.png
English: Schematic representation of the genome organization and functional domains of S protein for SARS-CoV and MERS-CoV. The single-stranded RNA genomes of SARS-CoV and MERS-CoV encode two large genes, the ORF1a and ORF1b genes, which encode 16 non-structural proteins (nsp1–nsp16) that are highly conserved throughout coronaviruses. The structural genes encode the structural proteins, spike (S), envelope (E), membrane (M), and nucleocapsid (N), which are common features to all coronaviruses. The accessory genes (shades of green) are unique to different coronaviruses in terms of number, genomic organization, sequence, and function. The structure of each S protein is shown beneath the genome organization. The S protein mainly contains the S1 and S2 subunits. The residue numbers in each region represent their positions in the S protein of SARS and MERS, respectively. The S1/S2 cleavage sites are highlighted by dotted lines. SARS-CoV, severe acute respiratory syndrome coronavirus; MERS-CoV, Middle East respiratory syndrome coronavirus; CP, cytoplasm domain; FP, fusion peptide; HR, heptad repeat; RBD, receptor-binding domain; RBM, receptor-binding motif; SP, signal peptide; TM, transmembrane domain.
Русский: Схематическое изображение организации генома и функциональных доменов S-белков вирусов SARS-CoV и MERS-CoV. Одноцепочечные РНК-геномы SARS-CoV и MERS-CoV содержат два больших гена - ORF1a и ORF1b, которые кодируют 16 неструктурных белков (nsp1–nsp16), которые у короронавирусов являются высоко консерватиными. Структурные гены кодируют структурные белки - S (шип), E (оболочка), M (Мембрана) и N (нуклеокапсид), которые являются общими элементами всех коронавирусов. Вспомогательные гены (оттенки зелёного) уникальны для конкретных коронавирусов по своему количеству, организации генома, последовательности и функции. S-белок в основном состоит из из субъединиц S1 и S2. Числа в каждом из участков обозначают их позицию в S-белках соответственно SARS и MERS. Сайты расщепления S1/S2 отмечены пунктирной линией. SARS-CoV - коронавирус тяжёлого острого респираторного синдрома; MERS-CoV - коронавирус ближневосточного респираторного синдрома; CP - цитоплазмический домен; FP - пептид слияния; HR - heptad repeat (участок повторения семи аминокислот); RBD - рецептор-связывающий домен; RBM - рецептор-связывающий мотив; SP - сигнальный пептид; TM - трансмембранный домен.
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Captions
Schematic representation of the genome organization and functional domains of S protein for SARS-CoV and MERS-CoV.
Схематическое изображение организации генома и функциональных доменов S-белков вирусов SARS-CoV и MERS-CoV.
Përfaqësimi skematik i organizatës gjenomike dhe fushave funksionale të proteinës S për SARS-CoV dhe MERS-CoV.
জিনোম অর্গানাইজেশনের পরিকল্পনামূলক উপস্থাপনা এবং SARS-CoV এবং MERS-CoV এর S প্রোটিনের কার্যকরী ডোমেন।
Uploaded a work by Zhiqi Song, Yanfeng Xu, Linlin Bao, Ling Zhang, Pin Yu, Yajin Qu, Hua Zhu, Wenjie Zhao, Yunlin Han and Chuan Qin; Fang Li, Lanying Du (Eds.) from https://www.mdpi.com/books/pdfview/book/1893 Zhiqi Song, Yanfeng Xu, Linlin Bao, Ling Zhang, Pin Yu, Yajin Qu, Hua Zhu, Wenjie Zhao, Yunlin Han and Chuan Qin From SARS to MERS, Thrusting Coronaviruses into the Spotlight Received: 16 December 2018; Accepted: 9 January 2019; Published: 14 January 2019 // Fang Li, Lanying Du (Eds.)...