File:PMC5109578 1349-7235-55-3047-g001.png

License

Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Summary

Author:Ikue Okamura, Yukitsugu Nakamura, Yuka Katsurada, Ken Sato, Takashi Ikeda, and Fumihiko Kimura,Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, Department of Hematology and Oncology, Dokkyo Medical University School of Medicine,Department of Laboratory Medicine, National Defence Medical College Hospital, Division of Hematology, Department of Internal Medicine, National Defence Medical College (Openi/National Library of Medicine) Source:https://openi.nlm.nih.gov/detailedresult?img=PMC5109578_1349-7235-55-3047-g001&query=&req=4 Description:g001: Macroscopic and microscopic findings of the skin lesion. (A) Palpable purpura progressed rapidly into extensive ecchymoses on the back (left), trunk (right upper), and right foot and ankle (right lower). (B) A fascia biopsy of the right crus showing fresh fibrin thrombi (arrows), including neutrophils within a small dilated vessel [Hematoxylin and Eosin (H&E) staining; original magnification 20×]. (C) A skin biopsy showing infiltration of neutrophils with karyorrhectic nuclear debris, and extravasation of erythrocytes around small vessels in the dermis, leading to a diagnosis of leukocytoclastic vasculitis (H&E staining; original magnification 20×). (D) A skin biopsy showing immunoglobulin M and C3 deposition within the walls of a small vessel in the dermis (immunofluorescence stain; original magnification 20×).