File:PMC4995732 BJH-174-767-g001 (1) (1).png

English⧼Colon⧽ bjh14132-fig-0001: Morphological appearances of chronic lymphocytic leukaemia (CLL) and CLL with >10% circulating prolymphocytes (CLL/PL). (A) Typical CLL. The majority of cells are small with clumped chromatin. (B) Typical CLL/PL. There is a mixture of prolymphocytes and typical CLL lymphocytes. (C) Typical CLL/PL showing small lymphocytes, prolymphocytes and an immunoblast. (D) Typical B‐cell prolymphocytic leukaemia (B‐PLL). The majority of cells have condensed non‐clumped chromatin and a single vesicular nucleolus. This panel is shown here for comparative purposes only, to illustrate the similar morphology of the prolymphocytes in B‐PLL to those seen in panels B and C. The majority of cells in B‐PLL are prolymphocytes and no small lymphocytes are seen. The usual “CLL score” is 0–1. B‐PLL is a distinct disorder and does not arise from a pre‐existing CLL. Magnification: panels A, B and C ×100; panel D ×60.