File:PMC4865657 fmicb-07-00715-g003.png

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DescriptionPMC4865657 fmicb-07-00715-g003.png	English⧼Colon⧽ F3: Human cytomegalovirus (HCMV)-derived secretome and virus latency. HCMV latency is established in bone marrow cells and is carried out in CD34+ hematopoietic progenitor cells and in CD14+ monocytes. (A) Latently infected CD34+ cells secrete CCL2/MCP-1 and CCL8/MCP-2 cytokines that recruit CD14+ monocytes and CD4+ Th1 cells to latently infected cells. However, the secretion of highly immunosuppressive cellular IL-10 and TGF-β inhibit proliferation and the antiviral functions of CD4+ Th1 cells. (B) Upon differentiation of CD14+ monocytes into mature macrophages or dendritic cells, reactivation of HCMV IE gene expression is promoted and the viral lytic gene program is initiated.
Date	2016
Source	https://openi.nlm.nih.gov/detailedresult?img=PMC4865657_fmicb-07-00715-g003&query=human%20cytomegalovirus&it=xg&req=4&npos=14
Author	Luganini A, Terlizzi ME, Gribaudo G

{{subst:Custom license marker added by UW}} https://creativecommons.org/licenses/by/4.0/ Attribution 4.0 International (CC BY 4.0)

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