File:PMC4832069 ncomms11303-f1.png

License

Attribution 4.0 International (CC BY 4.0)

Summary

Author:Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH,Toronto General Research Institute, University Health Network (Openi/National Library of Medicine) Source:https://openi.nlm.nih.gov/detailedresult?img=PMC4832069_ncomms11303-f1&query=Familial%20atrial%20fibrillation&it=xg&req=4&npos=12 Description:f1: Kindred with familial atrial fibrillation caused by mutation of MYL4.(a) Kindred structure. Affected members with AF are denoted by black filled symbols; subject III.5 is half-filled, reflecting a partial phenotype. Family members with unknown phenotype are filled grey. Protein alterations encoded at the MYL4 locus are indicated. (b) Electrocardiogram of index case (subject III.3) demonstrating atrial fibrillation with slow ventricular rate response while off medication. (c) Electrocardiogram of sister of the index case (subject III.2) during normal sinus rhythm. Arrows point to very low amplitude P-waves. Prolonged PR interval (atrial–ventricular conduction time) is also present.