File:PMC4498840 ccr30003-0349-f1.png

English⧼Colon⧽ fig01: Clinicopathologic features of cervical nodular lymphocyte-predominant Hodgkin lymphoma. (A) Sagittal view of sonography shows a large cervical mass (5.3 × 3.9 cm) involving cervical wall and parametrium (UB, urinary bladder; Ut, uterus; Va, vagina). (B) The cervical tumor shows dense infiltration of lymphoid cells in a large nodular pattern (4×, H&E). (C) Large atypical cells possess scant cytoplasm, multilobated popcorn-like nuclei and small basophilic nucleoli (arrow and inset, 400×, H&E). (D) The tumor cells in B-cell-rich nodules are immunoreactive for CD20 in the intensity stronger than background small B cells (200×, CD20) and the multilobated nuclei of L&H cells are highlighted in upper inset (400×, CD20). CD3-positive T-cell rosette surrounding L&H cells is indicated in lower inset (400×, CD3). (E) CD21 highlights the meshwork of follicular dendritic cells in the nodules (40×, CD21) and also stains the tumor cells by double staining of CD21 (red) and PAX5 (brown, insets, 400×).