File:PMC4369279 acn30002-0295-f2.png

English⧼Colon⧽ MRI Findings. (A) sMRI (Nov 2011/10 months after disease onset) displaying a T2- hyperintense lesion on level Th3 (A1) with Gd-enhancement on T1w (A2) on sagittal sequences. (B) sMRI (Dec 2012/24 months after disease onset) showing a new cervical lesion on level C6 with T2 hyperintense signal, edema, zonal appearance (B1), and rim-enhancing pattern (B2). (C) cMRI (Dec 2012/24 months after disease onset), showing a sharply demarcated, zonally composed pontomesencephalic lesion across the midline. A tigroid or leopard pattern was noted on T2-weighted sequences with multiple small focal zones of normal white matter signal within the area of confluent signal hyperintensity (C1) and a rim-enhancing pattern after Gd administration (C2). (D) cMRI D1 (T2w) + D2 (T1w +Gd), Aug 2013/32 months after disease onset: bihemispheric, sharply demarcated confluent tumefactive parieto-occipital lesion across the splenium of the corpus callosum with rim-enhancing pattern. sMRI, spinal magnetic resonance imaging; cMRI, cerebral magnetic resonance imaging.