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English⧼Colon⧽ fig03: Differential diagnosis of diffuse large B-cell lymphoma and Burkitt lymphoma. (A) Burkitt lymphoma (BL). Each cell has a slight pleomorphism compared with a typical BL case. (B) BL. Although a starry sky pattern is shown, cells are large and pleomorphic. However, these cells are CD10+, CD20+, BCL-6+, and BCL-2−, with a Ki67 index of >90% and MYC rearrangement. (C) BL. The starry sky pattern is not clear, but some tingible body macrophages are observed. Cells have greater nuclear pleomorphism than those in typical BL. These cells are also CD10+, CD20+, BCL-6+, and BCL-2−, with a Ki67 index of >90% and MYC rearrangement, indicating the BL phenotype. (D) Diffuse large B-cell lymphoma (DLBCL) with MYC rearrangement. The cells in this case were CD10+, CD20+, BCL-6+, and BCL-2−, with MYC rearrangement and a Ki67 index of >90%. Extremely large cell morphology and severe nuclear pleomorphism without the starry sky pattern indicates DLBCL.