License
Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
Summary
Author:Schlüter A, Espinosa L, Fourcade S, Galino J, López E, Ilieva E, Morató L, Asheuer M, Cook T, McLaren A, Reid J, Kelly F, Bates S, Aubourg P, Galea E, Pujol A, Neurometabolic Diseases Laboratory and Institut de Neuropatologia de Bellvitge (Openi/National Library of Medicine) Source:https://openi.nlm.nih.gov/detailedresult?img=PMC3277307_ddr53608&query=Adrenoleukodystrophy&it=xg&req=4&npos=10 Description: DDR536F8: The role of oxidative stress in ALD progression in spinal cord is already manifesting as early as 3.5 months of age. The picture shows dysregulated gene expression, induced (red triangle) and repressed (green triangle), of processes and components involved in ROS generation (black stars) and antioxidant defense (white stars). Perturbations in oxidative phosphorylation, iron and calcium homeostasis and changes in GSH homeostasis may altogether represent causes and consequences of increased oxidative stress. ROS might activate NF-κB leading to the regulation of genes involved in cell survival and inflammation. 12-Hydroxyeicosatetrenoate (12-HETE), arachidonate 12-lipoxygenase (ALOX12), ATPase, Ca2+ transporting, cardiac muscle, slow twitch 2 (ATP2A2), ATPase, Ca2+ transporting, plasma membrane 1 (ATP2B1), calcium-channel, voltage-dependent, alpha 2/delta subunit 3 (CACNA2D3), calcium-channel, voltage-dependent, gamma subunit 5 (CACNG5), calcium-channel, voltage-dependent, L-type, alpha 1D subunit (CACNA1D), calcium/calmodulin-dependent protein kinase (CaM kinase) II delta (CAMK2D), calmodulin 1 (CALM1), protein phosphatase 3, catalytic subunit, alpha isoform (PPP3CA), ceruloplasmin (CP), coenzyme Q10 (CQ), coproporphyrinogen oxidase (CPOX), cystathionine beta-synthase (CBS), cytochrome b-245 (CYBA), cytochrome c (CytC), DLST, dihydroxyacetone-phosphate (DHAP), electron transport chain complexes I:V (C-I:C-V), epoxide hydrolase 1, microsomal (EPHX1), glucose-6-phosphate dehydrogenase X-linked (G6PDH), GCLC, GRX, GSH, glutathione disulfide (GSSG), GPX, glutathione reductase (GSR), GST, GSS, glyceraldehyde-3-phosphate (G3P), glycerol-3-phosphate dehydrogenase (GPDH), glyoxalase 1 (GLO1), glyoxylate reductase/hydroxypyruvate reductase (GRHPR), nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (NFKBIA or IκBα), conserved helix–loop–helix ubiquitous kinase (CHUK or IKKα), inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB or IKKβ), inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG or IKKγ), lipid hydroperoxide (LOOH), lipid hydroxide (LOH), malic enzyme (ME), NADPH oxidase 1 (NOX1), nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 and 2 (NF-κB1 and NF-κB2), OGDH, PRX, phosphodiesterase 1A, calmodulin-dependent (PDE1A), PGPX, phosphorylase kinase, alpha 1 (PHKA1), pyruvate dehydrogenase (PDH), solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), thioredoxin (TRX), TCA, triosephosphate isomerase 1 (TPI), uncoupling protein 2 (UCP2), uroporphyrinogen decarboxylase (UROD), uroporphyrinogen III synthase (UROS).
