File:PBP catalysis.svg

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Original file ‎(SVG file, nominally 1,142 × 1,567 pixels, file size: 1.44 MB)

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Summary

Description
English: Diagram depicting formation of cross-links in the bacterial cell wall by a penicillin binding protein (PBP, an enzyme).

1. The bacterial cell wall consists of strands of repeating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) subunits. The NAM subunits have short peptide chains attached to them. (The exact composition of these can vary. The proximal alanine is usually L-ala and the distal two are usually D-ala.) These chains, in turn, are bound to chains of 5 glycine residues that will be used in cross-linking.

2. The PBP forms a bond with the peptide side chain at the second most distal alanine residue. This displaces the most distal alanine residue.

3. Another strand of bacterial cell wall arrives. The free end of one of the pentaglycine chains displaces the PBP and forms a bond with the terminal alanine on the other strand.

4. After being displaced, the PBP diffuses away.

5. The formation of one cross-link is complete.
Date
Source Own work
Author Mcstrother
Other versions

[edit]

  • Cross-linking of bacteria cell wall with no antibiotics.
    Cross-linking of bacteria cell wall with no antibiotics.
  • Action of penicillin
    Action of penicillin
  • Resistance to penicillin via modified cross-linking enzyme.
    Resistance to penicillin via modified cross-linking enzyme.
  • Action of vancomycin and resistance via alteration of peptide side-chains.
    Action of vancomycin and resistance via alteration of peptide side-chains.
  • Spanish version.
    Spanish version.

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inception

6 March 2011

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Date/TimeThumbnailDimensionsUserComment
current19:26, 9 September 2011Thumbnail for version as of 19:26, 9 September 20111,142 × 1,567 (1.44 MB)commons>McstrotherMajor revision. Corrected inaccuracies in previous image.

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