File:Fibrinogen variants.svg

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Summary

Description
English: Two relatively common human fibrinogen variants that form via alternative splicing.

Top: γA/γ' is a hexamer of γ', γA, 2 Aαs and 2 Bβs. γ' is rarer than γA. γ' has an extended C-terminal. Even rarer γ'/γ' combination can exist.

Bottom: rare fibrinogen-420 has a mass of 420 kDa. The C-terminals of its γ-chains are extended (αEC).

  • Cyan: Aα or extended α chains
  • Red: Bβ chains
  • Pink: γA or γ' chains
  • Green (Ca2+): calcium ions
  • Orange: carbohydrates bound covalently to C-terminal domains of Bβ chains
  • FpA: fibrinopeptides A
  • FpB: fibrinopeptides B
  • αC: Aα chain C-terminal domain
  • D: D domain
  • E: E domain

Source for info (picture adapted from figure 3.4):

Date
Source Own work
Author 5-HT2AR

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14 November 2019

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