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Summary
DescriptionFibrinogen to fibrin coagulation.svg
English: Blood soluble fibrinogens turn to insoluble fibrins to facilitate blood clotting.
1. FpAs are cut off by thrombin. New N-terminals link to γA chains of D domains and protofibrils begin to form.
2. FpBs are cut off by thrombin a bit later. New N-terminals link to Bβ chains of D domains. αCs previously bound by FpBs are also released. αCs allow for bi- and equilateral branching.
3. XIIIa cross-links fibrins (dark blue lines). C-terminal γA-γA- and Aα-Aα-cross-links form.
Cyan: Aα chains
Red: Bβ chains
Pink: γA chains
FpA: fibrinopeptides A
FpB: fibrinopeptides B
αC: Aα chain C-terminal domain
D: D domain
E: E domain
IIa: thrombin
XIIIa: factor XIIIa (activated form)
Bi: bilateral branching
Eq: equilateral branching
Source for info (picture adapted from figure 3.1):
(2018) Cardiovascular thrombus, Academic Press, pp. 31–43 ISBN: 9780128126165.
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