File:Clopidogrel activation.svg
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Size of this PNG preview of this SVG file: 533 × 323 pixels. Other resolutions: 320 × 194 pixels | 640 × 388 pixels | 1,024 × 621 pixels | 1,280 × 776 pixels | 2,560 × 1,551 pixels.
Original file (SVG file, nominally 533 × 323 pixels, file size: 110 KB)
Summary
| Description |
English: Clopidogrel (top left) being activated. The active metabolite (top right) has Z configuration at the double bond C3–C16 and possibly R configuration at the newly asymmetric C4.
The first step is a cytochrome P450 mediated oxidation; the two structures at the bottom are tautomers of each other; and the final step is a hydrolysis. |
| Date | |
| Source | Own work, based on Pereillo JM, Maftouh M, Andrieu A, Uzabiaga MF, Fedeli O, Savi P, Pascal M, Herbert JM, Maffrand JP, Picard C (2002). "Structure and stereochemistry of the active metabolite of clopidogrel". Drug Metab. Dispos. 30 (11): 1288–95. DOI:10.1124/dmd.30.11.1288. PMID 12386137. |
| Author | Anypodetos |
This W3C-invalid structural formula was created with BKchem-Inkscape.
Licensing
I, the copyright holder of this work, hereby publish it under the following license:
 
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This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication. |
| The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.
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File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 12:47, 24 December 2011 | | 533 × 323 (110 KB) | commons>Anypodetos | Fix stereochemistry |
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