Ferric derisomaltose

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Ferric derisomaltose
Names
Trade namesMonoferric
Other namesIron isomaltoside 1000[1]
  • iron(3+);(2S,3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexane-1,2,3,4,5-pentol
Clinical data
Drug classIron preparation[2]
Main usesIron deficiency anemia[3]
Side effectsRash, nausea, iron overload, infection, allergic reactions[2][1]
Routes of
use		Intravenous (IV)
External links
AHFS/Drugs.comMonograph
Legal
License data
Legal status
Chemical and physical data
FormulaC18H34FeO16+3
Molar mass562.299 g·mol−1
3D model (JSmol)
  • C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(CO)O)O)O)O)O)O)O)O)O)O)O.[Fe+3]
  • InChI=1S/C18H34O16.Fe/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18;/h5-30H,1-4H2;/q;+3/t5-,6+,7+,8+,9+,10+,11+,12+,13-,14-,15+,16+,17-,18-;/m0./s1
  • Key:JTQTXQSGPZRXJF-DOJSGGEQSA-N

Ferric derisomaltose, sold under the brand name Monoferric, is a medication used to treat iron deficiency anemia (IDA).[3] Specifically it is used in people who cannot take iron by mouth or who have non-hemodialysis dependent chronic kidney disease (NDD-CKD).[3] It is given by injection into a vein.[3]

Common side effects include rash and nausea.[3] Other side effects may iron overload, infection, and allergic reactions.[2][1] Safety in pregnancy is unclear, and some recommend not using in the 1st trimester.[4] It is an iron preparation.[2]>

Ferric derisomaltose was approved for medical use in the United States in 2020.[3] In the United Kingdom 1 gram costs the NHS about £170 in 2021.[1] In the United States this amount costs about 2,600 USD.[5]

Medical uses

Dosage

For those over 50 kg, it is given as a dose of 1,000 mg while for those under 50 kg a dose of 20mg/kg is used.[3]

References

  1. ↑ 1.0 1.1 1.2 1.3 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1068. ISBN 978-0857114105.
  2. ↑ 2.0 2.1 2.2 2.3 "Ferric Derisomaltose Monograph for Professionals". Drugs.com. Retrieved 10 December 2021.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 "Monoferric- ferric derisomaltose solution". DailyMed. 24 January 2020. Archived from the original on 1 October 2020. Retrieved 16 February 2020.
  4. ↑ "Ferric derisomaltose (Monoferric) Use During Pregnancy". Drugs.com. Retrieved 10 December 2021.
  5. ↑ "Monoferric Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 10 December 2021.

External links

Identifiers:
  • "Ferric derisomaltose". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 17 February 2020. Retrieved 31 March 2021.
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