Extracellular matrix protein FRAS1 is a protein that in humans is encoded by the FRAS1 (Fraser syndrome 1) gene.[5][6] This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development.
Metastatic prostate cancer
A single nucleotide switch (polymorphism) in FRAS1 promoter region is associated with metastatic Prostate cancer. The promoter region is directly related to the NFkB pathway and has been shown to be associated with lethal prostate cancer. [7]
Fras1 related extracellular matrix (FREM1[8]) directly relates to congenital diaphragmatic hernia in developing fetuses. Decreased expression of FREM1 may be linked with disruptions in the growth of diaphragm cells. Both FRAS1 and FREM1 are among the proteins that are primarily interacting during embryonic development. It is shown that a decrease in these two proteins lead to an increase of congenital diaphragmatic hernia in both humans and mice.[9]
Short K, Wiradjaja F, Smyth I (July 2007). "Let's stick together: the role of the Fras1 and Frem proteins in epidermal adhesion". IUBMB Life. 59 (7): 427–435. doi:10.1080/15216540701510581. PMID17654118. S2CID6690146.
Long J, Wei Z, Feng W, Yu C, Zhao YX, Zhang M (February 2008). "Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1". Journal of Molecular Biology. 375 (5): 1457–1468. doi:10.1016/j.jmb.2007.11.088. hdl:10397/14647. PMID18155042.
van Haelst MM, Maiburg M, Baujat G, Jadeja S, Monti E, Bland E, et al. (September 2008). "Molecular study of 33 families with Fraser syndrome new data and mutation review". American Journal of Medical Genetics. Part A. 146A (17): 2252–2257. doi:10.1002/ajmg.a.32440. PMID18671281. S2CID44521706.
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