FGR (gene)

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FGR
Identifiers
AliasesFGR, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, FGR proto-oncogene, Src family tyrosine kinase
External IDsOMIM: 164940 MGI: 95527 HomoloGene: 3842 GeneCards: FGR
Orthologs
SpeciesHumanMouse
Entrez

2268

14191

Ensembl

ENSG00000000938

ENSMUSG00000028874

UniProt

P09769

P14234

RefSeq (mRNA)

NM_001042729
NM_001042747
NM_005248

NM_010208

RefSeq (protein)

NP_001036194
NP_001036212
NP_005239

NP_034338

Location (UCSC)Chr 1: 27.61 – 27.64 MbChr 4: 132.7 – 132.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.[5][6]

Function

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein–Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[6]

Discovery

The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.[7]

Interactions

FGR (gene) has been shown to interact with Wiskott–Aldrich syndrome protein.[8][9][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000000938 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028874 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6595–9. Bibcode:1985PNAS...82.6595T. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.
  6. ^ a b "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog".
  7. ^ Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology. 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.
  8. ^ Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I (Aug 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Current Biology. 6 (8): 981–8. Bibcode:1996CBio....6..981B. doi:10.1016/S0960-9822(02)00642-5. PMID 8805332. S2CID 162267.
  9. ^ Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O, Hsuan JJ, Kellie S (Oct 1996). "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains" (PDF). The Journal of Biological Chemistry. 271 (42): 26291–5. doi:10.1074/jbc.271.42.26291. PMID 8824280. S2CID 1945958.
  10. ^ Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC (Oct 1995). "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology. 15 (10): 5725–31. doi:10.1128/MCB.15.10.5725. PMC 230823. PMID 7565724.

Further reading


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