Epomediol

Epomediol
Clinical data
Other names	1,3,3-Trimethyl-2-oxabicyclo [2.2.2]octane-6,7-endo,endo-diol
ATC code	A05BA05 (WHO) ;
Identifiers
	IUPAC name (1s,4r,6R,7S)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane-6,7-diol;
CAS Number	56084-15-2 ;
PubChem CID	115056;
ChemSpider	102967;
UNII	KFU4XSK3BK;
CompTox Dashboard (EPA)	DTXSID70971470 ;
Chemical and physical data
Formula	C10H18O3
Molar mass	186.251 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC1CC2C(OC1(C)C(O)C2)(C)C;

Epomediol (trade name Clesidren) is a synthetic terpenoid with choleretic effects. It has been used in the symptomatic treatment of itching due to intrahepatic cholestasis of pregnancy.^[1]^[2]^[3]

References

^ Gonzalez MC, Iglesias J, Tiribelli C, et al. (September 1992). "Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy". J Hepatol. 16 (1–2): 241–2. doi:10.1016/S0168-8278(05)80122-9. PMID 1484159.
^ Reyes H (December 1992). "The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy". Gastroenterol Clin North Am. 21 (4): 905–21. PMID 1478743.
^ Reyes H, Simon FR (August 1993). "Intrahepatic cholestasis of pregnancy: an estrogen-related disease". Semin Liver Dis. 13 (3): 289–301. doi:10.1055/s-2007-1007357. PMID 8235718.

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v t e Bile and liver therapy (A05)
Bile therapy	bile acid Chenodeoxycholic acid Cholic acid Obeticholic acid Ursodeoxycholic acid Ursodoxicoltaurine Cyclobutyrol Hymecromone Nicotinyl methylamide Piprozolin
Liver therapy	Arginine glutamate Citiolone Epomediol Glycyrrhizin Metadoxine Ornithine oxoglutarate Silymarin Tidiacic arginine