Eggerthella lenta

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Eggerthella lenta
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Scientific classification edit
Domain: Bacteria
Phylum: Actinomycetota
Class: Coriobacteriia
Order: Eggerthellales
Family: Eggerthellaceae
Genus: Eggerthella
Species:
E. lenta
Binomial name
Eggerthella lenta
Eggerth, 1935[1]

Eggarthella lenta is a Gram-positive, anaerobic species of bacteria which comprises part of the human microbiome. It has been found in the human gastrointestinal tract, female reproductive system and male prostate.[2] Occasionally it can cause disease by spreading to other areas, including bloodstream infections, liver abscesses, bacterial vaginosis and meningitis.[2]

E. lenta levels are enriched in inflammatory bowel disease, and the bacterium has been shown to activate T helper 17 cells. It has been shown to worsen colitis in mice models.[3] E. lenta has been found to be present in higher levels in the gut of people with Graves' disease.[4]

E. lenta has been shown to inactivate the cardiac drug digoxin.[5]

The species was known until 1999 as Eubacterium lentum.[6]

References

  1. Eggerth, Arnold H. (September 1935). "The Gram-positive Non-spore-bearing Anaerobic Bacilli of Human Feces". Journal of Bacteriology. 30 (3): 277–299. doi:10.1128/jb.30.3.277-299.1935. ISSN 0021-9193. PMC 543656. PMID 16559837.
  2. 2.0 2.1 Jiang, Shuming; E, Jianfei; Wang, Dengchao; Zou, Yanjiao; Liu, Xiao; Xiao, Hualiang; Wen, Yuan; Chen, Zongyao (2021-09-20). "Eggerthella lenta bacteremia successfully treated with ceftizoxime: case report and review of the literature". European Journal of Medical Research. 26 (1): 111. doi:10.1186/s40001-021-00582-y. ISSN 2047-783X. PMC 8454090. PMID 34544476. Archived from the original on 2023-10-20. Retrieved 2023-09-04.
  3. Alexander, Margaret; Ang, Qi Yan; Nayak, Renuka R.; Bustion, Annamarie E.; Sandy, Moriah; Zhang, Bing; Upadhyay, Vaibhav; Pollard, Katherine S.; Lynch, Susan V.; Turnbaugh, Peter J. (2022-01-12). "Human gut bacterial metabolism drives Th17 activation and colitis". Cell Host & Microbe. 30 (1): 17–30.e9. doi:10.1016/j.chom.2021.11.001. ISSN 1931-3128. PMC 8785648. PMID 34822777.
  4. Zhu, Qiyun; Hou, Qiangchuan; Huang, Shi; Ou, Qianying; Huo, Dongxue; Vázquez-Baeza, Yoshiki; Cen, Chaoping; Cantu, Victor; Estaki, Mehrbod; Chang, Haibo; Belda-Ferre, Pedro (November 2021). "Compositional and genetic alterations in Graves' disease gut microbiome reveal specific diagnostic biomarkers". The ISME Journal. 15 (11): 3399–3411. doi:10.1038/s41396-021-01016-7. PMC 8528855. PMID 34079079.
  5. Haiser, Henry J.; Gootenberg, David B.; Chatman, Kelly; Sirasani, Gopal; Balskus, Emily P.; Turnbaugh, Peter J. (2013-07-19). "Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta". Science. 341 (6143): 295–298. Bibcode:2013Sci...341..295H. doi:10.1126/science.1235872. PMC 3736355. PMID 23869020.
  6. Kageyama, A.; Benno, Y.; Nakase, T. (October 1999). "Phylogenetic evidence for the transfer of Eubacterium lentum to the genus Eggerthella as Eggerthella lenta gen. nov., comb. nov". International Journal of Systematic Bacteriology. 49 (4): 1725–1732. doi:10.1099/00207713-49-4-1725. ISSN 0020-7713. PMID 10555354.