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Other names: Vesicular dermatitis of hands and feet,[1] acute vesiculobullous hand eczema,[2] dyshidrotic dermatitis,[3] cheiropompholyx,[4] dyshidrotic eczema,[4] pompholyx,[4] podopompholyx[4]
The characteristic vesicles of dyshidrosis on a finger
SymptomsItchy blisters on the palms of the hands and bottoms of the feet[6]
ComplicationsSkin thickening[7]
Usual onsetOften recurrent[8]
DurationHeal over 3 weeks[7][8]
Diagnostic methodBased on symptoms[8]
Differential diagnosisPustular psoriasis, scabies[7]
TreatmentAvoiding triggers, barrier cream, steroid cream, antihistamines[6]
Frequency~1 in 2,000 (Sweden)[7]

Dyshidrosis is a type of dermatitis that is characterized by itchy blisters on the palms of the hands and bottoms of the feet.[6][9] Blisters are generally one to two millimeters in size and heal over three weeks.[7][8] However, they often recur.[8] Redness is not usually present.[7] Repeated attacks may result in fissures and skin thickening.[7]

The cause is unknown.[8] Triggers may include allergens, physical or mental stress, frequent hand washing, or metals.[8] Diagnosis is typically based on what it looks like and the symptoms.[8] Allergy testing and culture may be done to rule out other problems.[8] Other conditions that produce similar symptoms include pustular psoriasis and scabies.[7]

Avoiding triggers may be useful as may a barrier cream.[7] Treatment is generally with steroid cream.[8] High strength steroid creams may be required for the first week or two.[7] Antihistamines may be used to help with the itch.[8] If this is not effective steroid pills, tacrolimus, or psoralen plus ultraviolet A (PUVA) may be tried.[7][8]

About 1 in 2,000 people are affected in Sweden.[7] Males and females appear to be affected equally.[7] It explains about one in five cases of hand dermatitis.[10] The first description was in 1873.[7] The name comes from the word "dyshidrotic", meaning "difficult sweating", as problems with sweating was once believed to be the cause.[7]

Signs and symptoms

Dyshidrosis has been described as having the following characteristics:

  • Itchiness of the palms or soles, followed the a sudden development of intensely itchy small blisters on the sides of the fingers, the palms or the feet.[11]
  • These blisters are often described as having a "tapioca pudding" appearance.[12]
  • After a few weeks, the small blisters eventually disappear as the top layer of skin falls off.[7][13][14]
  • These eruptions do not occur elsewhere on the body.[7]
  • The eruptions may be symmetrical.[15]


The exact causes of dyshidrosis are unknown. Food allergens may be involved in certain cases.[13] Cases studies have implicated a wide range of foods including tuna, tomato, pineapple, chocolate, coffee, and spices among others.[13] A number of studies have implicated balsam of Peru.[13] A 2013 study found that dyshydrosis on the hands increased among those allergic to house dust mites, following inhalation of house dust mite allergen.[16]

Id reaction and irritant contact dermatitis are possible causes.[10]


Dyshidrosis is diagnosed based on symptoms, by gathering a patient's history and making observations.[8] Severity of symptoms can also be assessed using the dyshidrotic eczema area and severity index (DASI).[17] The DASI has been designed for clinical trials and is not typically used in practice.

Differential diagnosis


There are many treatments available for dyshidrosis. However, few of them have been developed or tested specifically on the condition.


About 1 in 2,000 people are affected in Sweden. Males and females appear to be affected equally.[7]


Dyshidrosis is also known as pompholyx,[1] a term originating from the Greek word for "bubble".[10]


  1. 1.0 1.1 "ICD-11 - ICD-11 for Mortality and Morbidity Statistics". icd.who.int. Archived from the original on 1 August 2018. Retrieved 26 September 2021.
  2. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. ISBN 0-7216-2921-0.
  3. "Pompholyx". Patient. 2014-02-26. Archived from the original on 3 August 2016. Retrieved 11 August 2016.
  4. 4.0 4.1 4.2 4.3 Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  5. "Dyshidrosis". Merriam-Webster Online. Merriam-Webster. 2014. Archived from the original on 15 April 2014. Retrieved 14 April 2014.
  6. 6.0 6.1 6.2 Lim, Henry W. (2020). "409. Eczemas, photodermatoses, papulomatoses, papulosquamous (including fungal) diseases, and figurate erythema: Eczema, dyshidrosis". In Goldman, Lee; Schafer, Andrew I. (eds.). Goldman-Cecil Medicine. Vol. 2 (26th ed.). Philadelphia: Elsevier. p. 2612. ISBN 978-0-323-53266-2. Archived from the original on 2023-04-28. Retrieved 2023-04-28.
  7. 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 Lofgren, SM; Warshaw, EM (December 2006). "Dyshidrosis: epidemiology, clinical characteristics, and therapy". Dermatitis : Contact, Atopic, Occupational, Drug. 17 (4): 165–81. doi:10.2310/6620.2006.05021. PMID 17150166.
  8. 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 Colomb-Lippa, D; Klingler, AM (July 2011). "Dyshidrosis". Journal of the American Academy of Physician Assistants. 24 (7): 54. PMID 21748961.
  9. "What Is Atopic Dermatitis? Fast Facts". NIAMS. November 2014. Archived from the original on 27 July 2016. Retrieved 11 August 2016.
  10. 10.0 10.1 10.2 Fitzpatrick, James (2016). "8". Dermatology Secrets Plus. Elsevier. pp. 70–81. ISBN 978-0-323-31029-1. Archived from the original on 2017-12-01. Retrieved 2017-11-27.
  11. Shelley, W. B. (1953-09-01). "Dysidrosis (pompholyx)". AMA Archives of Dermatology and Syphilology. 68 (3): 314–319. doi:10.1001/archderm.1953.01540090076008. ISSN 0096-5979. PMID 13079297.
  12. Bielan, Barbara (1996-04-01). "Dyshidrotic eczema". Dermatology Nursing. 8 (2). Archived from the original on 2017-04-02.
  13. 13.0 13.1 13.2 13.3 Veien, Niels K. (2009-07-01). "Acute and recurrent vesicular hand dermatitis". Dermatologic Clinics. 27 (3): 337–353, vii. doi:10.1016/j.det.2009.05.013. ISSN 1558-0520. PMID 19580928.
  14. Lofgren, Sabra M.; Warshaw, Erin M. (2006-12-01). "Dyshidrosis: epidemiology, clinical characteristics, and therapy". Dermatitis: Contact, Atopic, Occupational, Drug. 17 (4): 165–181. doi:10.2310/6620.2006.05021. ISSN 1710-3568. PMID 17150166.
  15. 15.0 15.1 15.2 Perry, Adam D.; Trafeli, John P. (2009-05-01). "Hand Dermatitis: Review of Etiology, Diagnosis, and Treatment". The Journal of the American Board of Family Medicine. 22 (3): 325–330. doi:10.3122/jabfm.2009.03.080118. ISSN 1557-2625. PMID 19429739.
  16. Schuttelaar ML, Coenraads PJ, Huizinga J, De Monchy JG, Vermeulen KM (2013). "Increase in vesicular hand eczema after house dust mite inhalation provocation: a double-blind, placebo-controlled, cross-over study" (PDF). Contact Dermatitis. 68 (2): 76–85. doi:10.1111/j.1600-0536.2012.02172.x. PMID 23046099. Archived (PDF) from the original on 2019-02-17. Retrieved 2019-02-05.
  17. Vocks, E.; Plötz, S. G.; Ring, J. (1999-01-01). "The Dyshidrotic Eczema Area and Severity Index – A score developed for the assessment of dyshidrotic eczema". Dermatology. 198 (3): 265–269. doi:10.1159/000018127. ISSN 1018-8665. PMID 10393450.
  18. "eMedicine – Dyshidrotic Eczema : Article by Camila K Janniger". Archived from the original on 2007-07-07. Retrieved 2007-07-10.
  19. BIRT AR (March 1964). "Drugs for Eczema of Children". Can Med Assoc J. 90 (11): 693–4. PMC 1922428. PMID 14127384.
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  21. Baron S, Moss C (February 2003). "Caustic burn caused by potassium permanganate". Arch. Dis. Child. 88 (2): 96. doi:10.1136/adc.88.2.96. PMC 1719457. PMID 12538301.
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  24. Ruzicka T, Lynde CW, Jemec GB, Diepgen T, Berth-Jones J, Coenraads PJ, et al. (April 2008). "Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial" (PDF). Br. J. Dermatol. 158 (4): 808–17. doi:10.1111/j.1365-2133.2008.08487.x. PMID 18294310. Archived (PDF) from the original on 2019-02-18. Retrieved 2019-02-05.
  25. Bollag W, Ott F (1999). "Successful treatment of chronic hand eczema with oral 9-cis-retinoic acid". Dermatology (Basel). 199 (4): 308–12. doi:10.1159/000018280. PMID 10640839.
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