Dyschromatosis symmetrica hereditaria
|Dyschromatosis symmetrica hereditaria|
|Other names: Reticulate acropigmentation of Dohi|
|Pale spots on darkened hands|
Dyschromatosis symmetrica hereditaria, also known as symmetrical dyschromatosis of the extremities, is a type of pigmentation disorder of the skin. It presents with progressively darkening skin with pale small flat spots appearing in a lace-like pattern typically on hands and feet.
It tends to run in families. Most are inherited as autosomal dominant, with a mutation of the ADAR1 gene.
It is rare, and presents primarily in the Japanese, but has also been found to affect individuals from Europe, India and the Caribbean.
Signs and symptoms
It presents with progressively darkening skin with pale small flat spots appearing in a lace-like pattern typically on hands and feet.
Most are inherited as autosomal dominant, with a mutation of the ADAR1 gene.
Diagnosis is by genetic testing.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "36. Disturbances of pigmentation". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 865. ISBN 978-0-323-54753-6.
- ↑ 2.0 2.1 Kono, Michihiro; Akiyama, Masashi (1 February 2019). "Dyschromatosis symmetrica hereditaria and reticulate acropigmentation of Kitamura: An update". Journal of Dermatological Science. 93 (2): 75–81. doi:10.1016/j.jdermsci.2019.01.004. ISSN 0923-1811. PMID 30692041.