Dowling–Degos disease

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Reticular pigmented anomaly of the flexures
Dowling-Degos disease (DermNet NZ colour-w-dowling-degos-3).jpg

Dowling–Degos disease (DDD), also known as reticular pigmented anomaly of the flexures, is a type of pigmentation disorder of the skin.[1] It typically presents with discolouration in skin folds such as underarms, neck, under breasts, and genital areas.[1]

It runs in families and generally appears in adolescence, although may present in later adulthood.[1] It is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.[2] DDD is associated with KRT5.[3]

See also


  1. 1.0 1.1 1.2 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "36. Disturbances of pigmentation: Dowling–Degos disease". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 866. ISBN 978-0-323-54753-6. Archived from the original on 2022-08-18. Retrieved 2022-08-12.
  2. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  3. Betz RC, Planko L, Eigelshoven S, et al. (March 2006). "Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease". Am. J. Hum. Genet. 78 (3): 510–9. doi:10.1086/500850. PMC 1380294. PMID 16465624.

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