Dolichyldiphosphatase
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| dolichyldiphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.1.43 | ||||||||
| CAS no. | 73361-26-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a dolichyldiphosphatase (EC 3.6.1.43) is an enzyme that catalyzes the chemical reaction
- dolichyl diphosphate + H2O dolichyl phosphate + phosphate
Thus, the two substrates of this enzyme are dolichyl diphosphate and H2O, whereas its two products are dolichyl phosphate and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dolichyl-diphosphate phosphohydrolase. Other names in common use include dolichol diphosphatase, dolichyl pyrophosphatase, dolichyl pyrophosphate phosphatase, dolichyl diphosphate phosphohydrolase, and Dol-P-P phosphohydrolase. This enzyme participates in n-glycan biosynthesis.
References
- Naumov AV, Shabalin YA, Vagabov VM, Kulaev IS. "Two pathways of dephosphorylation of dolichyl diphosphate in yeasts". Biochemistry. 50. Moscow: 551–556.
