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Combination of
MisoprostolProstaglandin analog
Trade namesArthrotec, Misofen, other
Clinical data
Main usesRheumatoid arthritis, osteoarthritis[1]
Side effectsAbdominal pain, diarrhea, nausea, gastritis, dizziness, low red blood cells[1]
  • Contraindication[1]
Routes of
By mouth[1]
External links
Legal status

Diclofenac/misoprostol, sold under the brand name Arthrotec, is a combination medication used to treat rheumatoid arthritis or osteoarthritis in those at high risk of NSAID-induced gastroduodenal ulceration.[1] It is taken by mouth.[1]

Common side effects include abdominal pain, diarrhea, nausea, gastritis, dizziness, and low red blood cells.[1] Other side effects may include liver problems, high blood pressure, heart failure, kidney problems, anaphylaxis, and worsening asthma.[1] Use in pregnancy may harm the baby or result in abortion.[1] It contains diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID) and misoprostol a gastrointestinal (GI) protective prostaglandin E1.[1]

The combination was approved for medical use in the United States in 1997.[1] It is available as a generic medication.[2] In the United States 60 tablets costs about 40 USD as of 2023.[2] In the United Kingdom 60 tablets costs the NHS about £12 as of 2021.[3]

Medical uses


It may be taken at a dose of up to 50 mg diclofenac/200 mcg misoprostol three to four times per day.[1]

Society and culture


This medication is in the U.S. available for $57 (USD) for an amount of 30 tablets (50 mg-200 mcg) [4]


  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 "DailyMed - ARTHROTEC- diclofenac sodium and misoprostol tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 25 September 2021. Retrieved 25 May 2023.
  2. 2.0 2.1 "Diclofenac Sodium/Misoprostol". GoodRx. Retrieved 25 May 2023.
  3. BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1183. ISBN 978-0857114105.
  4. "Diclofenac/misoprostol Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 29 October 2015. Retrieved 27 March 2021.

External links