Diadenosine hexaphosphate hydrolase (ATP-forming)

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Diadenosine hexaphosphate hydrolase (ATP-forming)
Identifiers
EC no.3.6.1.61
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Diadenosine hexaphosphate hydrolase (ATP-forming) (EC 3.6.1.61, Ndx1) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming).[1] This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O 2 ATP
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O ATP + ADP
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O ATP + AMP

The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+).

References

  1. ^ Iwai T, Kuramitsu S, Masui R (May 2004). "The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity". The Journal of Biological Chemistry. 279 (21): 21732–9. doi:10.1074/jbc.m312018200. PMID 15024014.

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