Dextranomer

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Dextranomer
Clinical data
Trade namesDebrisan
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Topical
ATC code
Identifiers
  • Dextran, 2,3-dihydroxypropyl 2-hydroxy-1,3-propanediyl ethers
CAS Number
PubChem SID
ChemSpider
  • none
UNII
ECHA InfoCard100.128.106 Edit this at Wikidata
 ☒NcheckY (what is this?)  (verify)

Dextranomer (trade name Debrisan, Exudex[1]) is a cicatrizant used in dressings for wound healing,[2] and in pharmaceutical products to treat fecal incontinence.[3] It consists of dextran polymer chains cross-linked into a three-dimensional network.[4]

Solesta

Solesta is the marketed brand name of a system of injections of dextranomer in stabilized sodium hyaluronate for use in fecal incontinence (FI).[5] This preparation is a biocompatible gel, for use as a perianal injectable bulking agent. The system is intended to be injected in the submucosal layer of the proximal anal canal (i.e. above the level of the dentate line).

References

  1. ^ "Establishment Registration & Device Listing".
  2. ^ Parulkar BG, Sobti MK, Pardanani DS (1985). "Dextranomer dressing in the treatment of infected wounds and cutaneous ulcers". J Postgrad Med. 31 (1): 28–33. PMID 2413198.
  3. ^ "Solesta Gel Approved for Fecal Incontinence - Drugs.com MedNews".
  4. ^ Solesta Package Insert
  5. ^ Hoy, SM (Aug 20, 2012). "Dextranomer in stabilized sodium hyaluronate (Solesta): in adults with faecal incontinence". Drugs. 72 (12): 1671–8. doi:10.2165/11209030-000000000-00000. PMID 22845415. S2CID 6499631.

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