Dextran 40

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Dextran 40
Names
Trade namesLMD, Rheomacrodex, others
Other namesLow viscosity dextran[1]
Clinical data
Drug classColloid[1]
Main usesExpand blood volume[2]
Side effectsVolume overload, kidney problems, acidosis, allergic reactionss, poor blood clotting[2]
Pregnancy
category
  • US: Intravenous
External links
AHFS/Drugs.comMonograph
US NLMDextran 40
Legal
Legal status
Chemical and physical data
Molar mass70,000 Da

Dextran 40, sold under the brand name LMD among others, is a type of fluid given by injection into a vein to expand blood volume.[2] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available.[2] However, it does not carry oxygen.[3]

Side effects may include volume overload, kidney problems, acidosis, allergic reactionss, and poor blood clotting.[2] It is not recommended in severe kidney failure, heart failure, or clotting disorders.[2] Use may interfere with certain blood tests.[2]

Dextran 40 came into medical use in 1961.[4] It is a glucose polymer with a typical molecular weight of 40 kDa.[1][4] It works by pulling fluid from the extravascular space into the blood vessels.[2] It is a non protein based colloid solution.[2][1]

Medical uses

Other uses may include as a starting fluid for extracorporeal circulation.[1] And to decrease the risk of blood clots during certain surgeries.[1]

Dosage

In adults the first half liter may give given rapidly.[2] In children 5 to 10 mL/kg may be used.[2]

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 "DailyMed - LMD IN DEXTROSE- dextran 40 injection, solution LMD IN SODIUM CHLORIDE- dextran 40 injection, solution". dailymed.nlm.nih.gov. Archived from the original on 14 April 2021. Retrieved 23 December 2021.
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 "Dextran 40 Monograph for Professionals". Drugs.com. Archived from the original on 3 January 2017. Retrieved 22 July 2021.
  3. Howe, Tiffany; Burton, Angela (10 December 2019). Pharmacology for the Surgical Technologist - E-Book. Elsevier Health Sciences. p. 155. ISBN 978-0-323-66122-5. Archived from the original on 11 January 2022. Retrieved 23 December 2021.
  4. 4.0 4.1 Alexander, Martin; Bloom, Barry R.; Hopwood, David A.; Hull, Roger; Iglewski, Barbara H.; Laskin, Allen I.; Oliver, Stephen G.; Schaechter, Moselio; Summers, William C. (10 February 2000). Encyclopedia of Microbiology, Four-Volume Set. Academic Press. p. 562. ISBN 978-0-08-054848-7. Archived from the original on 11 January 2022. Retrieved 23 December 2021.

External links

Identifiers:
  • "Dextran 70". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2021-08-28. Retrieved 2021-07-22.