Dextran 40

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Dextran 40
Names
Trade namesLMD, Rheomacrodex, others
Other namesLow viscosity dextran[1]
Clinical data
Drug classColloid[1]
Main usesExpand blood volume[2]
Side effectsVolume overload, kidney problems, acidosis, allergic reactionss, poor blood clotting[2]
Pregnancy
category
  • US: Intravenous
External links
AHFS/Drugs.comMonograph
Legal
Legal status
Chemical and physical data
Molar mass70,000 Da

Dextran 40, sold under the brand name LMD among others, is a type of fluid given by injection into a vein to expand blood volume.[2] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available.[2] However, it does not carry oxygen.[3]

Side effects may include volume overload, kidney problems, acidosis, allergic reactionss, and poor blood clotting.[2] It is not recommended in severe kidney failure, heart failure, or clotting disorders.[2] Use may interfere with certain blood tests.[2]

Dextran 40 came into medical use in 1961.[4] It is a glucose polymer with a typical molecular weight of 40 kDa.[1][4] It works by pulling fluid from the extravascular space into the blood vessels.[2] It is a non protein based colloid solution.[2][1]

Medical uses

Other uses may include as a starting fluid for extracorporeal circulation.[1] And to decrease the risk of blood clots during certain surgeries.[1]

Dosage

In adults the first half liter may give given rapidly.[2] In children 5 to 10 mL/kg may be used.[2]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "DailyMed - LMD IN DEXTROSE- dextran 40 injection, solution LMD IN SODIUM CHLORIDE- dextran 40 injection, solution". dailymed.nlm.nih.gov. Archived from the original on 14 April 2021. Retrieved 23 December 2021.
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 "Dextran 40 Monograph for Professionals". Drugs.com. Archived from the original on 3 January 2017. Retrieved 22 July 2021.
  3. ↑ Howe, Tiffany; Burton, Angela (10 December 2019). Pharmacology for the Surgical Technologist - E-Book. Elsevier Health Sciences. p. 155. ISBN 978-0-323-66122-5. Archived from the original on 11 January 2022. Retrieved 23 December 2021.
  4. ↑ 4.0 4.1 Alexander, Martin; Bloom, Barry R.; Hopwood, David A.; Hull, Roger; Iglewski, Barbara H.; Laskin, Allen I.; Oliver, Stephen G.; Schaechter, Moselio; Summers, William C. (10 February 2000). Encyclopedia of Microbiology, Four-Volume Set. Academic Press. p. 562. ISBN 978-0-08-054848-7. Archived from the original on 11 January 2022. Retrieved 23 December 2021.

External links

Identifiers:
  • "Dextran 70". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2021-08-28. Retrieved 2021-07-22.
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