DCTN2

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DCTN2
Identifiers
AliasesDCTN2, DCTN50, DYNAMITIN, HEL-S-77, RBP50, dynactin subunit 2
External IDsOMIM: 607376 MGI: 107733 HomoloGene: 4667 GeneCards: DCTN2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001261412
NM_001261413
NM_006400

NM_001190453
NM_001190454
NM_027151

RefSeq (protein)

NP_001177382
NP_001177383
NP_081427

Location (UCSC)n/aChr 10: 127.1 – 127.12 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Dynactin subunit 2 is a protein that in humans is encoded by the DCTN2 gene[4][5]

Function

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 23 subunits (11 individual proteins ranging in size from 22 to 150 kD).[6] The subunit is commonly referred to as p50 or dynamitin.[4] Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that bind to two copies of p150-glued (DCTN1) and two copies of p24 (DCTN3) to form the dynactin shoulder domain.[6]

Interactions

DCTN2 has been shown to interact with MARCKSL1.[7]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025410 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB (February 1996). "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis". The Journal of Cell Biology. 132 (4): 617–33. doi:10.1083/jcb.132.4.617. PMC 2199864. PMID 8647893.
  5. ^ "Entrez Gene: DCTN2 dynactin 2 (p50)".
  6. ^ a b Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP (March 2015). "The structure of the dynactin complex and its interaction with dynein". Science. 347 (6229): 1441–1446. Bibcode:2015Sci...347.1441U. doi:10.1126/science.aaa4080. PMC 4413427. PMID 25814576.
  7. ^ Yue L, Lu S, Garces J, Jin T, Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". The Journal of Biological Chemistry. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182.

Further reading