Cyclin B2

CCNB2
Identifiers
Aliases	CCNB2, HsT17299, Cyclin B2
External IDs	OMIM: 602755 MGI: 88311 HomoloGene: 74359 GeneCards: CCNB2
Gene location (Human) Chr. Chromosome 15 (human) Band 15q22.2 Start 59,105,126 bp End 59,125,045 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 D Start 70,314,974 bp End 70,328,829 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte embryo ganglionic eminence sperm spongy bone bone marrow thymus amniotic fluid bone marrow cells Top expressed in dermis seminiferous tubule medial ganglionic eminence abdominal wall spermatid thymus endocardial cushion secondary oocyte yolk sac primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cyclin-dependent protein serine/threonine kinase activity cadherin binding protein kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding Cellular component microtubule cytoskeleton centrosome membrane nucleus cytosol cyclin-dependent protein kinase holoenzyme complex cytoplasm Biological process T cell homeostasis thymus development cell division cell cycle mitotic nuclear membrane disassembly in utero embryonic development G2/M transition of mitotic cell cycle regulation of cell cycle growth regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle protein phosphorylation regulation of mitotic nuclear division positive regulation of cell population proliferation regulation of growth positive regulation of cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9133 12442 Ensembl ENSG00000157456 ENSMUSG00000032218 UniProt O95067 P30276 RefSeq (mRNA) NM_004701 NM_007630 RefSeq (protein) NP_004692 NP_031656 Location (UCSC) Chr 15: 59.11 – 59.13 Mb Chr 9: 70.31 – 70.33 Mb PubMed search
Wikidata
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G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Function

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.

Interactions

Cyclin B2 has been shown to interact with TGF beta receptor 2.

See also

• Cyclin B

Further reading

• He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR (1995). "Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity". J. Virol. 69 (11): 6705–11. doi:10.1128/JVI.69.11.6705-6711.1995. PMC 189580. PMID 7474080.
• Re F, Braaten D, Franke EK, Luban J (1995). "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. Virol. 69 (11): 6859–64. doi:10.1128/JVI.69.11.6859-6864.1995. PMC 189600. PMID 7474100.
• Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau NR (1995). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr". J. Virol. 69 (12): 7909–16. doi:10.1128/JVI.69.12.7909-7916.1995. PMC 189735. PMID 7494303.
• Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS (1995). "The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle". J. Virol. 69 (10): 6304–13. doi:10.1128/JVI.69.10.6304-6313.1995. PMC 189529. PMID 7666531.
• Jackman M, Firth M, Pines J (1995). "Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus". EMBO J. 14 (8): 1646–54. doi:10.1002/j.1460-2075.1995.tb07153.x. PMC 398257. PMID 7737117.
• Pines J, Hunter T (1994). "The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B". EMBO J. 13 (16): 3772–81. doi:10.1002/j.1460-2075.1994.tb06688.x. PMC 395290. PMID 8070405.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Poon B, Jowett JB, Stewart SA, Armstrong RW, Rishton GM, Chen IS (1997). "Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard". J. Virol. 71 (5): 3961–71. doi:10.1128/JVI.71.5.3961-3971.1997. PMC 191548. PMID 9094673.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Kao GD, Muschel RJ, Weiner DB (1998). "HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3419–24. Bibcode:1998PNAS...95.3419M. doi:10.1073/pnas.95.7.3419. PMC 19851. PMID 9520381.
• Brandeis M, Rosewell I, Carrington M, Crompton T, Jacobs MA, Kirk J, Gannon J, Hunt T (1998). "Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4344–9. Bibcode:1998PNAS...95.4344B. doi:10.1073/pnas.95.8.4344. PMC 22491. PMID 9539739.
• Felzien LK, Woffendin C, Hottiger MO, Subbramanian RA, Cohen EA, Nabel GJ (1998). "HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5281–6. Bibcode:1998PNAS...95.5281F. doi:10.1073/pnas.95.9.5281. PMC 20252. PMID 9560267.
• Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY (1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene. 18 (1): 269–75. doi:10.1038/sj.onc.1202263. PMID 9926943.
• Elder RT, Yu M, Chen M, Edelson S, Zhao Y (2000). "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint". Virus Res. 68 (2): 161–73. doi:10.1016/S0168-1702(00)00167-2. PMID 10958988.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
• Mouland AJ, Coady M, Yao XJ, Cohen EA (2002). "Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression". Virology. 292 (2): 321–30. doi:10.1006/viro.2001.1261. PMID 11878934.