Cyclic-guanylate-specific phosphodiesterase
Jump to navigation
Jump to search
| Cyclic-guanylate-specific phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.4.52 | ||||||||
| CAS no. | 338732-46-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cyclic-guanylate-specific phosphodiesterase (EC 3.1.4.52, cyclic bis(3′→5')diguanylate phosphodiesterase, c-di-GMP-specific phosphodiesterase, c-di-GMP phosphodiesterase, phosphodiesterase, phosphodiesterase A1, PDEA1, VieA) is an enzyme with systematic name cyclic bis(3′→5′)diguanylate 3-guanylylhydrolase.[1][2][3][4][5] This enzyme catalyses the following reaction:
- cyclic di-3′,5′-guanylate + H2O 5′-phosphoguanylyl(3′→5′)guanosine
This enzyme requires Mg2+ or Mn2+ for activity. It is inhibited by Ca2+ and Zn2+.
References
- ^ Chang, A.L.; Tuckerman, J.R.; Gonzalez, G.; Mayer, R.; Weinhouse, H.; Volman, G.; Amikam, D.; Benziman, M.; Gilles-Gonzalez, M.A. (2001). "Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor". Biochemistry. 40 (12): 3420–3426. doi:10.1021/bi0100236. PMID 11297407.
- ^ Christen, M.; Christen, B.; Folcher, M.; Schauerte, A.; Jenal, U. (2005). "Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP". J. Biol. Chem. 280 (35): 30829–30837. doi:10.1074/jbc.M504429200. PMID 15994307.
- ^ Schmidt, A.J.; Ryjenkov, D.A.; Gomelsky, M. (2005). "The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains". J. Bacteriol. 187 (14): 4774–4781. doi:10.1128/JB.187.14.4774-4781.2005. PMC 1169503. PMID 15995192.
- ^ Tamayo, R.; Tischler, A.D.; Camilli, A. (2005). "The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase". J. Biol. Chem. 280 (39): 33324–33330. doi:10.1074/jbc.M506500200. PMC 2776828. PMID 16081414.
- ^ Chua SL, Liu Y, Yam JK, Tolker-Nielsen T, Kjelleberg S, Givskov M, Yang L (2014). "Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles". Nature Communications. 5: 4462. Bibcode:2014NatCo...5.4462C. doi:10.1038/ncomms5462. PMID 25042103.
External links
- Cyclic-guanylate-specific+phosphodiesterase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
