Copper (64Cu) oxodotreotide

From WikiProjectMed
Jump to navigation Jump to search
Copper (64Cu) oxodotreotide
INN: Copper (64Cu) oxodotreotide
Copper (64Cu) oxodotreotide.svg
Names
Trade namesDetectnet
Other namesCopper Cu 64 dotatate
  • 2-[4-[2-[[(2R)-1-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-4-[[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-10-(carboxylatomethyl)-7-(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;copper-64(2+)
Clinical data
Drug classRadioactive diagnostic agent[1]
Main usesPositron emission tomography (PET) of neuroendocrine tumors (NETs)[1]
Side effectsNausea, vomiting, flushing[1]
Pregnancy
category
  • US: N (Not classified yet)
Routes of
use
Intravenous
External links
US NLMCopper (64Cu) oxodotreotide
Legal
License data
Legal status
Chemical and physical data
FormulaC65H88CuN14O19S2
Molar mass1497.16 g·mol−1
3D model (JSmol)
  • CC(C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)CN6CCN(CCN(CCN(CC6)CC(=O)[O-])CC(=O)[O-])CC(=O)O)C(=O)NC(C(C)O)C(=O)O)O.[Cu+2]
  • InChI=1S/C65H90N14O19S2.Cu/c1-38(80)56-64(96)73-51(63(95)75-57(39(2)81)65(97)98)37-100-99-36-50(72-59(91)47(28-40-10-4-3-5-11-40)68-52(83)32-76-20-22-77(33-53(84)85)24-26-79(35-55(88)89)27-25-78(23-21-76)34-54(86)87)62(94)70-48(29-41-15-17-43(82)18-16-41)60(92)71-49(30-42-31-67-45-13-7-6-12-44(42)45)61(93)69-46(58(90)74-56)14-8-9-19-66;/h3-7,10-13,15-18,31,38-39,46-51,56-57,67,80-82H,8-9,14,19-30,32-37,66H2,1-2H3,(H,68,83)(H,69,93)(H,70,94)(H,71,92)(H,72,91)(H,73,96)(H,74,90)(H,75,95)(H,84,85)(H,86,87)(H,88,89)(H,97,98);/q;+2/p-2/t38-,39-,46+,47-,48+,49-,50+,51+,56+,57+;/m1./s1/i;1+0
  • Key:IJRLLVFQGCCPPI-NVGRTJHCSA-L

Copper (64Cu) oxodotreotide, sold under the brand name Detectnet, is a radioactive diagnostic agent used in positron emission tomography (PET) of neuroendocrine tumors (NETs).[1] Specifically it is used in adults with somatostatin receptor positive disease.[1] It is given by injection into a vein.[1]

Common side effects include nausea, vomiting, and flushing.[1] Other side effects include radiation exposure and allergic reactions.[1] It interacts with somatostatin analogs.[1] Use during pregnancy may harm the baby.[1] It works by binding to somatostatin receptor, particularly subtype 2 receptors.[1]

Copper (64Cu) oxodotreotide was approved for medical use in the United States in 2020.[1] In the United States it costs about 3,900 USD for a vial as of 2022.[2]

Medical uses

Dosage

It is typically used at a dose of 148 MBq (4 mCi).[1]

History

The U.S. Food and Drug Administration (FDA) approved copper 64Cu dotatate based on data from two trials that evaluated 175 adults.[3]

Trial 1 evaluated adults, some of whom had known or suspected NETs and some of whom were healthy volunteers.[3] The trial was conducted at one site in the United States (Houston, TX).[3] Both groups received copper 64Cu dotatate and underwent PET scan imaging.[3]

Trial 2 data came from the literature-reported trial of 112 adults, all of whom had history of NETs and underwent PET scan imaging with copper 64Cu dotatate.[3] The trial was conducted at one site in Denmark.[3] In both trials, copper 64Cu dotatate images were compared to either biopsy results or other images taken by different techniques to detect the sites of a tumor.[3] The images were read as either positive or negative for presence of NETs by three independent image readers who did not know participant clinical information.[3]

See also

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 "Detectnet- copper cu 64 dotatate injection, solution". DailyMed. 14 September 2020. Archived from the original on 1 November 2022. Retrieved 24 September 2020.
  2. "Detectnet Prices, Coupons, Copay & Patient Assistance". Drugs.com. Archived from the original on 22 May 2022. Retrieved 3 November 2022.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 "Drug Trials Snapshots: Detectnet". U.S. Food and Drug Administration (FDA). 3 September 2020. Archived from the original on 21 September 2020. Retrieved 10 September 2020. Public Domain This article incorporates text from this source, which is in the public domain.

External links

Identifiers: