Chronic mucocutaneous candidiasis
|Chronic mucocutaneous candidiasis|
|Other names: CMCFamilial chronic mucocutaneous candidiasis ,CARD9 deficiency, Invasive candidiasis-deep dermatophytosis syndrome|
|This condition is due to T-cells(immune) disorder|
|Specialty||Infectious diseases, dermatology|
|Types||CANDF1,2,3,4,5,6,7,8 and 9j|
|Diagnostic method||Thyroid function test, Liver function test|
|Treatment||Systemic antifungal therapy|
Chronic mucocutaneous candidiasis is an immune disorder of T cells, it is characterized by chronic infections with Candida that are limited to mucosal surfaces, skin, and nails.: 310 It can also be associated with other types of infections, such as HIV
The 9 types of Chronic mucocutaneous candidiasis are the following:
Symptoms and signs
Associated Diseases or Conditions
There are a number of disorders associated with chronic mucocutaneous candidiasis including endocrine dysfunctions, vitiligo, malabsorption syndromes, neoplasms and others. In most people, chronic mucocutaneous candidiasis is correlated to abnormalities in cell mediated immunity (T-lymphocyte mediated response)
The T-lymphocytes fail to produce the necessary cytokines that are required for immunity against Candida. Current effective treatments include antifungal drugs and, for long term remissions, restoration of cellular immunity.
Chronic mucocutaneous candidiasis can be inherited either autosomal dominant or autosomal recessive. There are 9 types of this condition with the first CANDF1 being located at 2p22.3-p21 (cytogenetically).
All nine types carry information to create proteins involved in the human immune response to infections that attack the body (fungal)
The mechanism of the human immune system has it normally fighting in an infection (like Candida). Initially Th17 cells are made by the immune system, which in turn produces interleukin-17 (IL-17). Inflammation is induced and white blood cells confront infection.
Chronic mucocutaneous candidiasis mutations affect IL-17 by inhibiting its pathway. This in turn affects the human immune systems ability to fight infection, in total there are 9 possible types of this condition.
The majority of the nine genes lead to chronic mucocutaneous candidiasis, however CARD9 gene mutations is solely responsible for causing systemic candidiasis 
- Systemic antifungal therapy (e.g. Fluconazole)
- Transfer factor
- Combination therapy
- Screening (annually)
The frequency of this condition,Chronic mucocutaneous candidiasis, is unknown at this time.
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