Chronic eosinophilic leukemia
|Chronic eosinophilic leukemia|
|Other names: CEL|
Signs and symptoms
Infiltration of eosinophils causes organ damage.
CEL not otherwise specified (CEL NOS) is a form in which BCR-ABL1 fusion genes and PDGFRA, PDGFRB, and FGFR1 rearrangements are not found.
For a diagnosis of CEL, hypereosinophilia with greater than 30% eosinophils is required. Serum IgE is usually normal. In cases associated with PDGFRB, serum vitamin B12 and tryptase may be elevated.
The management for Chronic eosinophilic leukemia is systemic steroids, and hydroxyurea
CEL associated with a mutation in PDGFRA is treatable with imatinib and has an excellent prognosis. On the other hand, CEL associated with FGFR1 mutations has a very poor prognosis. Progression can occur from CEL to AEL or AML in rare cases.
Cases occur in people of all ages. The disease is more common in males than females.
- "Chronic Eosinophilic Leukemia". The Lecturio Medical Concept Library. Archived from the original on 9 July 2021. Retrieved 8 July 2021.
- Jaffe, Elaine (2016-08-25). Hematopathology (2 ed.). pp. 931–941. ISBN 978-0-323-29613-7.
- McPherson (2011). Henry's Clinical Diagnosis and Management by Laboratory Methods (23 ed.). Elsevier. pp. 606–658. ISBN 9781437709742.
- Hoffman, Ronald (2017-08-15). Hematology: basic principles and practice (Seven ed.). pp. 1151–1169. ISBN 978-0-323-35762-3.
- Aster, Jon. Hematopathology: A Volume in the High Yield Pathology Series. Elsevier. p. 222.
- Klion, Amy D. (29 October 2009). "How I treat hypereosinophilic syndromes". Blood. 114 (18): 3736–3741. doi:10.1182/blood-2009-07-143552. Archived from the original on 15 June 2022. Retrieved 24 June 2022.
- Chronic eosinophilic leukemia Archived 2015-04-18 at the Wayback Machine entry in the public domain NCI Dictionary of Cancer Terms
- Cancer.Net: Eosinophilic Leukemia Archived 2022-02-02 at the Wayback Machine