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Green nail due to pseudomonas infection with paronychia (DermNet NZ green-nail).jpg

Chromonychia is a discoloration of one or more nails.[1] It can be divided into melanonychia, leukonychia, red , green, yellow and blue nails.[1] It may be normal or provide a clue to diagnosing several diseases.[1]


Chromonychia can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia.[2] Although a few cytostatics may cause these changes, the drugs most commonly involved are adriamycin, cyclophosphamide and vincristine, or in polychemotherapy[3][4] Chromonychia is associated with AIDS. A significant association (p<0.05) was found between chromonychia and CD4 counts of below 200 per cubic millimeter.[5]


  1. 1.0 1.1 1.2 Cao, Lei; Shi, Ren-lin; Tan, Cheng; Bi, Xin Ling; Zang, Ru-Zhi; Chen, Liu-Qing; Yuan, Shan; Rigopoulos, Dimitris; Ma, Dong-Lai; Zhu, Wen-Yuan; Li, Heng-Jin; Yin, Zhi-Quiang (2018). "20. Disorders of skin appendages". In Zhu, Wen-Yuan; Tan, Cheng; Zhang, Ru-zhi (eds.). Atlas of Skin Disorders: Challenging Presentations of Common to Rare Conditions. Singapore: Springer. pp. 303–305. ISBN 978-981-10-8036-4. Archived from the original on 2022-04-14. Retrieved 2022-04-13.
  2. Unamuno P, Fernández-López E, Santos C (July 1992). "Leukonychia due to cytostatic agents". Clin. Exp. Dermatol. 17 (4): 273–4. doi:10.1111/j.1365-2230.1992.tb02166.x. PMID 1451320.
  3. Chapman S, Cohen PR (April 1997). "Transverse leukonychia in patients receiving cancer chemotherapy". South. Med. J. 90 (4): 395–8. doi:10.1097/00007611-199704000-00006. PMID 9114829.
  4. Dasanu, Constantin A; Vaillant, JG; Alexandrescu, DT (October 31, 2006). "Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma". Dermatology Online Journal. 12 (6): 10. PMID 17083890. Archived from the original on October 2, 2012. Retrieved December 19, 2020.
  5. Monsel G, Ly F, Canestri A, Diousse P, Ndiaye B, Caumes E (March 2008). "[Prevalence of skin disorders in HIV patients in Senegal and relationship to degree of immunosuppression]". Ann Dermatol Venereol (in français). 135 (3): 187–93. doi:10.1016/j.annder.2007.11.022. PMID 18374849.