Calcineurin inhibitor

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Calcineurin inhibitor
Drug class
Clinical data
Common typesCyclosporine, tacrolimus, pimecrolimus, voclosporin[1]

Calcineurin inhibitors are a class of medication used to decrease immune function.[1] They are used to treat atopic dermatitis, lupus, and interstitial lung disease.[2][1] They may be used after organ transplant.[1] They may be applied as a cream, take by mouth, or injected into a vein.[2]

Common side effects of creams include skin burning.[2] Lymphoma does not appear to be a concern with the creams.[2] They work by blocking the action of calcineurin.[3] Types include cyclosporine, tacrolimus, pimecrolimus and voclosporin.[2][1]

In Canada 30 grams of tacrolimus costs about 100 CAD as of 2023.[2]


The cost in Canada of tacrolimus cream at about 100 CAD as of 2023 is more than the alternative betamethasone cream at about 13 CAD.[2]


  1. 1.0 1.1 1.2 1.3 1.4 Safarini, Omar A.; Keshavamurthy, Chandana; Patel, Preeti (2023). "Calcineurin Inhibitors". StatPearls. StatPearls Publishing. Archived from the original on 18 April 2023. Retrieved 25 July 2023.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Ton, Joey (24 July 2023). "#345 Fancy Creams for Scaly Skin: Topical calcineurin inhibitors for atopic dermatitis (Free)". CFPCLearn. Archived from the original on 27 July 2023. Retrieved 25 July 2023.
  3. "List of Calcineurin inhibitors". Archived from the original on 23 December 2022. Retrieved 25 July 2023.