CYP3A43

CYP3A43
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1TQN, 1W0E, 1W0F, 1W0G, 2J0D, 2V0M, 3NXU, 3TJS, 3UA1, 4I3Q, 4I4G, 4I4H, 4K9T, 4K9U, 4K9V, 4K9W, 4K9X, 4NY4, 5A1P, 5A1R
Identifiers
Aliases	CYP3A43, cytochrome P450 family 3 subfamily A member 43
External IDs	OMIM: 606534 HomoloGene: 136124 GeneCards: CYP3A43
EC number	1.14.14.56
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 99,828,013 bp End 99,866,093 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver body of pancreas jejunal mucosa sperm skeletal muscle tissue prostate gastrocnemius muscle testicle pharynx n/a More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 64816 n/a Ensembl ENSG00000021461 n/a UniProt Q9HB55 n/a RefSeq (mRNA) NM_001278921 NM_022820 NM_057095 NM_057096 n/a RefSeq (protein) NP_001265850 NP_073731 NP_476436 NP_476437 n/a Location (UCSC) Chr 7: 99.83 – 99.87 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.

External links

• Human CYP3A43 genome location and CYP3A43 gene details page in the UCSC Genome Browser.

Further reading

• Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
• Finta C, Zaphiropoulos PG (2001). "The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons". Gene. 260 (1–2): 13–23. doi:10.1016/S0378-1119(00)00470-4. PMID 11137287.
• Westlind A, Malmebo S, Johansson I, et al. (2001). "Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43". Biochem. Biophys. Res. Commun. 281 (5): 1349–55. doi:10.1006/bbrc.2001.4505. PMID 11243885.
• Finta C, Zaphiropoulos PG (2002). "Intergenic mRNA molecules resulting from trans-splicing". J. Biol. Chem. 277 (8): 5882–90. doi:10.1074/jbc.M109175200. PMID 11726664.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Cauffiez C, Lo-Guidice JM, Chevalier D, et al. (2004). "First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant". Hum. Mutat. 23 (1): 101. doi:10.1002/humu.9211. PMID 14695544. S2CID 9162733.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Stone A, Ratnasinghe LD, Emerson GL, et al. (2005). "CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians". Cancer Epidemiol. Biomarkers Prev. 14 (5): 1257–61. doi:10.1158/1055-9965.EPI-04-0534. PMID 15894682.
• Thompson EE, Kuttab-Boulos H, Yang L, et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347. PMID 16314882.
• Shchepotina EG, Nikishina MV, Vavilin VA, Lyakhovich VV (2006). "Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia". Bull. Exp. Biol. Med. 140 (6): 726–8. doi:10.1007/s10517-006-0067-6. PMID 16848237. S2CID 11922749.