CHL1

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CHL1
Identifiers
AliasesCHL1, CALL, L1CAM2, cell adhesion molecule L1 like
External IDsOMIM: 607416 MGI: 1098266 HomoloGene: 21314 GeneCards: CHL1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253387
NM_001253388
NM_006614

NM_007697

RefSeq (protein)

NP_001240316
NP_001240317
NP_006605

NP_031723

Location (UCSC)Chr 3: 0.2 – 0.41 MbChr 6: 103.49 – 103.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene.[6]

CHL1 is a cell adhesion molecule closely related to the L1. In melanocytic cells CHL1 gene expression may be regulated by MITF,[7] and can act as a helicase protein during the interphase stage of mitosis.

The protein, however, has dynamic localisation, meaning that it has not only multiple roles in the cell, but also various locations.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134121 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030077 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pandey, G.; Kanwar, P.; Pandey, A. (2014). Global Comparative Analysis of CBL-CIPK Gene Families in Plants. Springer International Publishing. p. 52. ISBN 978-3-319-09078-8.
  6. ^ Wei MH, Karavanova I, Ivanov SV, Popescu NC, Keck CL, Pack S, Eisen JA, Lerman MI (September 1998). "In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules". Hum. Genet. 103 (3): 355–64. doi:10.1007/s004390050829. PMID 9799093. S2CID 3177127.
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading

External links