|Trade names||Mentax, Lotrimin Ultra, others|
|Other names||Butenafine hydrochloride|
|Main uses||Ringworm, pityriasis versicolor|
|Side effects||Itchiness, stinging|
|Elimination half-life||35–100 hours|
|Chemical and physical data|
|Molar mass||317.47 g·mol−1|
|3D model (JSmol)|
Common side effects include itchiness, and stinging. Other side effects may include allergic reactions. There is no evidence of harm in pregnancy; however, such use has not been well studied. It is a benzylamine, which is similar to allylamines, such as terbinafine. It is believed to work by affecting the cell membrane.
Butenafine is indicated for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur, as well as athlete's foot (Tinea pedis), ringworm (Tinea corporis) and jock itch (Tinea cruris) due to Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, and Trichophyton tonsurans.
There is some evidence that it is effective against dermatophyte infections of the toenails, but needs to be applied daily for prolonged periods (at least one year).
For 1% cream:
- for adults and children 12 years and older:
- wash the affected skin with soap and water and dry completely before applying
- apply once a day to affected skin for 2 weeks or as directed by a doctor
- wash hands after each use
- children under 12 years: ask a doctor
Butenafine is typically available as a 1% topical cream.
Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes. Lacking ergosterol, the cell membranes increase in permeability, allowing their contents to leak out. Furthermore, inhibition of squalene epoxidase leads to a toxic buildup of squalene. This double action of butenafine (increased membrane permeability and toxic buildup of squalene) makes butenafine fungicidal rather than merely fungistatic.
In addition to being an antifungal, butenafine is an anti inflammatory. Because fungal skin infections are often accompanied by significant inflammation, this is a desirable property. The fact that butenafine has intrinsic anti inflammatory properties is also desirable since it is not necessary to add cortical steroids (which decrease the ability to fight infection) to reduce inflammation.
- "Butenafine Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 12 January 2022.
- Mylan Pharmaceuticals Inc. "Mentax (butenafine hydrochloride) Cream. Human Prescription Drug Label". dailymed.nlm.nih.gov. National Institutes of Health, U.S. National Library of Medicine, Health & Human Services. Archived from the original on 28 August 2016. Retrieved 24 August 2016.
- "Butenafine topical Use During Pregnancy". Drugs.com. Archived from the original on 26 November 2020. Retrieved 12 January 2022.
- "Butenafine topical Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 12 January 2022.
- Crawford F, Hollis S (July 2007). "Topical treatments for fungal infections of the skin and nails of the foot". The Cochrane Database of Systematic Reviews (3): CD001434. doi:10.1002/14651858.CD001434.pub2. PMC 7073424. PMID 17636672.