Bullous drug reaction

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Bullous drug reaction
Other names: Bullous drug eruption,[1] generalized bullous fixed drug eruption, multilocular bullous fixed drug eruption[2]: 554 
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Intraepidermal spongiosis with necrotic keratinocytes

Bullous drug reaction most commonly refers to a drug reaction in the erythema multiforme group.[3]: 129  These are uncommon reactions to medications, with an incidence of 0.4 to 1.2 per million person-years for toxic epidermal necrolysis and 1.2 to 6.0 per million person-years for Stevens–Johnson syndrome.[3]: 129  The primary skin lesions are large erythemas (faintly discernible even after confluence), most often irregularly distributed and of a characteristic purplish-livid color, at times with flaccid blisters.[2]: 554 

See also


  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 470. ISBN 978-1-4160-2999-1.
  2. 2.0 2.1 Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  3. 3.0 3.1 James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.

External links

External resources