Brucellosis

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Brucellosis
Other names: Remitting fever, undulant fever, Mediterranean fever, Maltese fever, Malta fever, Gibraltar fever, Crimean fever, goat fever, Bang disease, rock fever[1][2]
Brucella spp. are seen mostly as single cells and appearing like “fine sand”.
SpecialtyInfectious disease
SymptomsFever, headache, muscle pains, joint pains[3]
ComplicationsTesticular inflammation, endocarditis, spleen enlargement[4]
Usual onset2 to 4 weeks after exposure[4]
TypesB. abortus, B. canis, B. melitensis, B. suis[1]
CausesBrucella[1]
Risk factorsUnpasteurized dairy products, undercooked meat[5]
Diagnostic methodBlood cultures, agglutination testing[1]
Differential diagnosisInfectious mononucleosis, malaria, leptospirosis, meningitis[1]
TreatmentAntibiotics[4]
PrognosisRecover can take 6 months[1]
Frequency>500,000 a year[6]
Deaths2% risk of death[1]

Brucellosis is an infection caused by bacteria of the Brucella type.[1] Symptoms may include fever, headache, muscle pains, and joint pains.[3] Symptoms typically occur 2 to 4 weeks after exposure and may come on gradually or suddenly.[4] Without treatment infection may lasts for years.[1] Complications may include testicular inflammation, endocarditis, miscarriage, septic arthritis, or enlargement of the spleen.[1][4]

Infections in humans are caused by four specific types of Brucella: B. abortus, B. canis, B. melitensis, and B. suis.[1] As few as 10 to 100 organisms can result in disease.[1] It most commonly spreads as a result of eating unpasteurized dairy products from infected animals.[5] It may also occur from eating undercooked meat or working with infected animals.[5] Rarely spread may occur between people.[5] Diagnosis is usually by blood cultures or agglutination testing.[1]

Treatment of those over the age of 8 is a combination of doxycycline and rifampin for 6 weeks.[4] Younger people may be treated with trimethoprim/sulfamethoxazole.[4] Different antibiotics may be used for complications.[4] Exercise may speed recovery.[1] Death occurs in 2% of cases.[1]

Over 500,000 cases are reported a year as of 2009.[6] In 2010, 115 cases were diagnosed in the United States.[1] Areas more commonly affected include those bordering the Mediterranean, Central and South America, Asia, Africa, and the Middle East.[7] In 2022, at least 46 cases occurred in Osh, Kyrgyzstan.[8] George Cleghorn gave the first description of the condition in 1751.[1] The disease is named for Sir David Bruce who led the organisation that identified the bacteria as the cause of the disease in 1886.[1]

Signs and symptoms

A person with brucellosis from before 1930

The symptoms are like those associated with many other febrile diseases. The duration of the disease can vary from a few weeks to many months.In the first stage of the disease, bacteremia occurs and leads to the classic triad of undulant fevers, sweating, and migratory arthralgia and myalgia.[3][9]

Gastrointestinal symptoms may include:[10]:

This complex is known as Malta fever.[11] During episodes of Malta fever, melitococcemia can usually be demonstrated by means of blood culture in tryptose medium or Albini medium. If untreated, the disease can give origin to focalizations or become chronic. The focalizations of brucellosis occur usually in bones and joints, and osteomyelitis or spondylodiscitis of the lumbar spine accompanied by sacroiliitis is very characteristic of this disease.The consequences of Brucella infection are highly variable and may include arthritis, spondylitis, thrombocytopenia, meningitis, uveitis, optic neuritis, endocarditis, and various neurological disorders collectively known as neurobrucellosis.[12][3][9][13]

Cause

Further information: Brucella

Brucellosis in humans is usually associated with consumption of unpasteurized milk and soft cheeses made from the milk of infected animals—primarily goats, infected with B. melitensis and with occupational exposure of laboratory workers, veterinarians, and slaughterhouse workers.[14]

Some vaccines used in livestock, most notably B. abortus strain 19, also cause disease in humans if accidentally injected.[12][15]

Overall findings support that brucellosis poses an occupational risk to goat farmers with specific areas of concern including weak awareness of disease transmission to humans and lack of knowledge on specific safe farm practices such as quarantine practices.[16]

  • Processed using the Gram-stain method, photomicrograph revealed the presence of numerous Gram-negative, coccobacillus, Brucella suis bacteria.

    Processed using the Gram-stain method, photomicrograph revealed the presence of numerous Gram-negative, coccobacillus, Brucella suis bacteria.

  • Granuloma and necrosis in the liver of a guinea pig infected with Brucella suis

    Granuloma and necrosis in the liver of a guinea pig infected with Brucella suis

Pathophysiology

In terms of the mechanism of this condition we find that Brucella organisms are phagocytosed and delivered to lymphoid tissue by macrophages. After arriving at the lymphatic system replication begins locally.[12]

Diagnosis

Blood agar plate culture of Brucella suis.

The diagnosis of brucellosis relies on:[12][17][18][19]

  1. Demonstration of the agent: blood cultures in tryptose broth, bone marrow cultures: The growth of brucellae is extremely slow.
  2. Demonstration of antibodies against the agent either with the classic Bengal Rose reactions, with ELISA for IgM antibodies associated with chronic disease
  3. Histologic evidence of granulomatous hepatitis on hepatic biopsy
  4. Radiologic alterations in infected vertebrae: the Pedro Pons sign and marked osteophytosis are suspicious of brucellic spondylitis.

Definite diagnosis of brucellosis requires the isolation of the organism from the blood, body fluids, or tissues, but serological methods may be the only tests available in many settings. Positive blood culture yield ranges between 40 and 70% and is less commonly positive for B. abortus than B. melitensis or B. suis. Identification of specific antibodies against bacterial lipopolysaccharide and other antigens can be detected by the standard agglutination test (SAT), rose Bengal, 2-mercaptoethanol (2-ME), antihuman globulin (Coombs’) and indirect enzyme-linked immunosorbent assay (ELISA). SAT is the most commonly used serology in endemic areas.[20][21]

An agglutination titre greater than 1:160 is considered significant in nonendemic areas[4].False-negative SAT may be caused by the presence of blocking antibodies in the α-globulin (IgG) fractions.[22]

Dipstick assays are new and promising, based on the binding of Brucella IgM antibodies, and are simple, accurate, and rapid. ELISA typically uses cytoplasmic proteins as antigens. It measures IgM, IgG, and IgA with better sensitivity and specificity than the SAT in most recent comparative studies.[23] The commercial Brucellacapt test, a single-step immunocapture assay for the detection of total anti-Brucella antibodies, is an increasingly used adjunctive test when resources permit. PCR is fast and should be specific. Many varieties of PCR have been developed (e.g. nested PCR, realtime PCR, and PCR-ELISA) and found to have superior specificity and sensitivity in detecting both primary infection and relapse after treatment.[24]

Other laboratory findings include normal peripheral white cell count, and occasional leucopenia with relative lymphocytosis. The serum biochemical profiles are commonly normal.[25]

Prevention

Surveillance using serological tests, as well as tests on milk such as the milk ring test, can be used for screening and play an important role in campaigns to eliminate the disease. Also, individual animal testing both for trade and for disease-control purposes is practiced. In endemic areas, vaccination is often used to reduce the incidence of infection. As the disease is closer to being eliminated, a test and eradication program is required to completely eliminate it.The main way of preventing brucellosis is by using fastidious hygiene in producing raw milk products, or by pasteurizing all milk that is to be ingested by human beings, either in its unaltered form or as a derivative, such as cheese.[26][27]

Treatment

Tetracycline

Antibiotics such as tetracyclines, doxycycline, and the aminoglycosides streptomycin and gentamicin are effective against Brucella bacteria. However, the use of more than one antibiotic is needed for several weeks.[28][12].

The gold standard treatment for adults is daily intramuscular injections of streptomycin 1 g for 14 days and oral doxycycline 100 mg twice daily for 45 days (concurrently). Gentamicin 5 mg/kg by intramuscular injection once daily for 7 days is an acceptable substitute when streptomycin is not available or contraindicated.[29] Another widely used regimen is doxycycline plus rifampin twice daily for at least 6 weeks. This regimen has the advantage of oral administration. A triple therapy of doxycycline, with rifampin and co-trimoxazole, has been used successfully to treat neurobrucellosis.[30] Doxycycline plus streptomycin regimen (for 2 to 3 weeks) is more effective than doxycycline plus rifampicin regimen (for 6 weeks).[31]

Doxycycline is able to cross the blood–brain barrier, but requires the addition of two other drugs to prevent relapse. [32][33][34] In brucellic endocarditis, surgery is required for an optimal outcome.[35]

Prognosis

The mortality of the disease is low. The most frequent cause of death was endocarditis. Recent advances in antibiotics and surgery have been successful in preventing death due to endocarditis. Prevention of human brucellosis can be achieved by eradication of the disease in animals by vaccination and other veterinary control methods such as testing herds/flocks and slaughtering animals when infection is present. Currently, no effective vaccine is available for humans. Boiling milk before consumption, or before using it to produce other dairy products, is protective against transmission via ingestion.[36][12][35]

Patients who have had brucellosis should probably be excluded indefinitely from donating blood or organs. Exposure of diagnostic laboratory personnel to Brucella organisms remains a problem in both endemic settings and when brucellosis is unknowingly imported by a patient.[37] After appropriate risk assessment, staff with significant exposure should be offered postexposure prophylaxis and followed up serologically for 6 months.[38] Recently published experience confirms that prolonged and frequent serological follow-up consumes significant resources without yielding much information, and is burdensome for the affected staff, who often fail to comply. The side effects of the usual recommended regimen of rifampicin and doxycycline for 3 weeks also reduces treatment adherence. As no evidence shows treatment with two drugs is superior to monotherapy, British guidelines now recommend doxycycline alone for 3 weeks and a less onerous follow-up protocol.[39]

Epidemiology

New cases of brucellosis per million people as of 2006.[40]

Argentina

According to a study published in 2002, an estimated 10–13% of farm animals are infected with Brucella species.[41] Annual losses from the disease were calculated at around $60 million. Since 1932, government agencies have undertaken efforts to contain the disease. Currently, all cattle of ages 3–8 months must receive the Brucella abortus strain 19 vaccine.[42]

Australia

Australia is free of cattle brucellosis, although it occurred in the past. Brucellosis of sheep or goats has never been reported. Brucellosis of pigs does occur. Feral pigs are the typical source of human infections.[43][44]

Canada

On 19 September 1985, the Canadian government declared its cattle population brucellosis-free. Brucellosis ring testing of milk and cream, and testing of cattle to be slaughtered ended on 1 April 1999. Monitoring continues through testing at auction markets, through standard disease-reporting procedures, and through testing of cattle being qualified for export to countries other than the United States.[45]

China

Historically speaking the infection was first detected in this country in 1905.[46]

An outbreak infecting humans took place in Lanzhou in 2020 after the Lanzhou Biopharmaceutical Plant, which was involved in vaccine production, accidentally pumped out the bacteria into the atmosphere in exhaust air due to use of expired disinfectant. The outbreak affected over 6,000 people.[47][48]

Disease incidence map of B. melitensis infections in animals in Europe during the first half of 2006
  never reported
  not reported in this period
  confirmed clinical disease
  confirmed infection
  no information

Malta

Until the early 20th century, the disease was endemic in Malta to the point of it being referred to as "Maltese fever". Since 2005, due to a strict regimen of certification of milk animals and widespread use of pasteurization, the illness has been eradicated from Malta.[49]

Republic of Ireland

Ireland was declared free of brucellosis on 1 July 2009. The disease had troubled the country's farmers and veterinarians for several decades.[50][51] The Irish government submitted an application to the European Commission, which verified that Ireland had been liberated.[51] Brendan Smith, Ireland's then Minister for Agriculture, Food and the Marine, said the elimination of brucellosis was "a landmark in the history of disease eradication in Ireland".[50][51] Ireland's Department of Agriculture, Food and the Marine intends to reduce its brucellosis eradication programme now that eradication has been confirmed.[50][51]

UK

Mainland Britain has been free of brucellosis since 1979, although there have been episodic re-introductions since.[52] The last outbreak of brucellosis in Great Britain was in cattle in Cornwall in 2004.[52][53] Northern Ireland was declared officially brucellosis-free in 2015.[52]

New Zealand

Brucellosis in New Zealand is limited to sheep (B. ovis). The country is free of all other species of Brucella.[54]

United States

Cases of brucellosis in humans in the United States from the years 1993–2010[55]

Dairy herds in the USA are tested at least once a year to be certified brucellosis-free.[56] with the Brucella milk ring test.[57]

Cows confirmed to be infected are often killed. This vaccination is usually referred to as a "calfhood" vaccination. Most cattle receive a tattoo in one of their ears, serving as proof of their vaccination status. This tattoo also includes the last digit of the year they were born.[58]

The first state–federal cooperative efforts towards eradication of brucellosis caused by B. abortus in the U.S. began in 1934.[59]

Brucellosis was originally imported to North America with non-native domestic cattle (Bos taurus), which transmitted the disease to wild bison (Bison bison) and elk (Cervus canadensis). No records exist of brucellosis in ungulates native to America until the early 19th century.[60]

History

Brucellosis first came to the attention of British medical officers in the 1850s in Malta during the Crimean War, and was referred to as Malta Fever. Jeffery Allen Marston (1831–1911) described his own case of the disease in 1861. The causal relationship between organism and disease was first established in 1887 by David Bruce.[61][62] In 1897, Danish veterinarian Bernhard Bang isolated a bacillus as the agent of heightened spontaneous abortion in cows.[63]

Maltese scientist and archaeologist Themistocles Zammit identified unpasteurized goat milk as the major etiologic factor of undulant fever in June 1905.[64]

In the late 1910s, American bacteriologist Alice C. Evans was studying the Bang bacillus and gradually realized that it was virtually indistinguishable from the Bruce coccus.[65] The short-rod versus oblong-round morphologic borderline explained the leveling of the erstwhile bacillus/coccus distinction (that is, these "two" pathogens were not a coccus versus a bacillus but rather were one coccobacillus).[65] The Bang bacillus was already known to be enzootic in American dairy cattle, which showed itself in the regularity with which herds experienced contagious abortion.[65] Having made the discovery that the bacteria were certainly nearly identical and perhaps totally so, Evans then wondered why Malta fever was not widely diagnosed or reported in the United States.[65] She began to wonder whether many cases of vaguely defined febrile illnesses were in fact caused by the drinking of raw (unpasteurized) milk.[65] During the 1920s, this hypothesis was vindicated. Such illnesses ranged from undiagnosed and untreated gastrointestinal upset to misdiagnosed[65] febrile and painful versions, some even fatal. This advance in bacteriological science sparked extensive changes in the American dairy industry to improve food safety. The changes included making pasteurization standard and greatly tightening the standards of cleanliness in milkhouses on dairy farms. The expense prompted delay and skepticism in the industry,[65] but the new hygiene rules eventually became the norm.

In the decades after Evans's work, this genus, which received the name Brucella in honor of Bruce, was found to contain several species with varying virulence. The name "brucellosis" gradually replaced the 19th-century names Mediterranean fever and Malta fever.[66]

In 1989, neurologists in Saudi Arabia discovered "neurobrucellosis", a neurological involvement in brucellosis.[67][68]

These obsolete names have previously been applied to brucellosis:[66][69]

  • Crimean fever
  • Cyprus fever
  • Gibraltar fever
  • Goat fever
  • Italian fever
  • Neapolitan fever
  • David Bruce (centre), with members of the Mediterranean Fever Commission (Brucellosis)

    David Bruce (centre), with members of the Mediterranean Fever Commission (Brucellosis)

  • The lab in which Sir Themistocles Zammit and the Mediterranean Fever Commission carried out research about brucellosis from 1904 to 1906 is located within the Castellania in Valletta, Malta.

    The lab in which Sir Themistocles Zammit and the Mediterranean Fever Commission carried out research about brucellosis from 1904 to 1906 is located within the Castellania in Valletta, Malta.

Biological warfare

Brucella species were weaponized by several advanced countries by the mid-20th century. In 1954, B. suis became the first agent weaponized by the United States at its Pine Bluff Arsenal near Pine Bluff, Arkansas. Brucella species survive well in aerosols and resist drying. Brucella and all other remaining biological weapons in the U.S. arsenal were destroyed in 1971–72 when the American offensive biological warfare program was discontinued by order of President Richard Nixon.[70]

Agent US was in advanced development by the end of World War II. When the United States Air Force (USAF) wanted a biological warfare capability, the Chemical Corps offered Agent US. Though the capability was developed, operational testing indicated the weapon was less than desirable, and the USAF designed it as an interim capability until it could eventually be replaced by a more effective biological weapon.[71][12]

Other animals

Species infecting domestic livestock are B. abortus (cattle), B. canis (dogs), B. melitensis (goats and sheep), B. ovis (sheep), and B. suis ( pigs).[72]

Cattle

B. abortus is the principal cause of brucellosis in cattle. The bacteria are shed from an infected animal at or around the time of calving or abortion. Once exposed, the likelihood of an animal becoming infected is variable, depending on age, pregnancy status, and other intrinsic factors of the animal, as well as the number of bacteria to which the animal was exposed.[73] The most common clinical signs of cattle infected with B. abortus are high incidences of abortions, arthritic joints, and retained placenta.[74][26]

Dogs

The causative agent of brucellosis in dogs, B. canis, is transmitted to other dogs through breeding and contact with aborted fetuses. Brucellosis can occur in humans who come in contact with infected aborted tissue or semen. The bacteria in dogs normally infect the genitals and lymphatic system, but can also spread to the eyes, kidneys, and intervertebral discs. Brucellosis in the intervertebral disc is one possible cause of discospondylitis. Symptoms of brucellosis in dogs include abortion in female dogs and scrotal inflammation and orchitis in males. Fever is uncommon. Infection of the eye can cause uveitis, and infection of the intervertebral disc can cause pain or weakness. Blood testing of the dogs prior to breeding can prevent the spread of this disease. It is treated with antibiotics, as with humans, but it is difficult to cure.[75]

Aquatic wildlife

Brucellosis in cetaceans is caused by the bacterium B. ceti. First discovered in the aborted fetus of a bottlenose dolphin, the structure of B. ceti is similar to Brucella in land animals. B. ceti is commonly detected in two suborders of cetaceans, the Mysticeti and Odontoceti. The Mysticeti include four families of baleen whales, filter-feeders, and the Odontoceti include two families of toothed cetaceans ranging from dolphins to sperm whales. B. ceti is believed to transfer from animal to animal through sexual intercourse, maternal feeding, aborted fetuses, placental issues, from mother to fetus, or through fish reservoirs. Brucellosis is a reproductive disease, so has an extreme negative impact on the population dynamics of a species. This becomes a greater issue when the already low population numbers of cetaceans are taken into consideration. B. ceti has been identified in four of the 14 cetacean families, but the antibodies have been detected in seven of the families. This indicates that B. ceti is common amongst cetacean families and populations. Only a small percentage of exposed individuals become ill or die. However, particular species apparently are more likely to become infected by B. ceti. The harbor porpoise, striped dolphin, white-sided dolphin, bottlenose dolphin, and common dolphin have the highest frequency of infection amongst ondontocetes. In the mysticetes families, the northern minke whale is by far the most infected species. Dolphins and porpoises are more likely to be infected than cetaceans such as whales. With regard to sex and age biases, the infections do not seem influenced by the age or sex of an individual. Although fatal to cetaceans, B. ceti has a low infection rate for humans.[76]

Terrestrial wildlife

Elk

The disease in its various strains can infect multiple wildlife species, including elk (Cervus canadensis), bison (Bison bison), African buffalo (Syncerus caffer), European wild boar (Sus scrofa), caribou (Rangifer tarandus), moose (Alces alces), and marine mammals .[77][78] While some regions use vaccines to prevent the spread of brucellosis between infected and uninfected wildlife populations, no suitable brucellosis vaccine for terrestrial wildlife has been developed.[79] This gap in medicinal knowledge creates more pressure for management practices that reduce spread of the disease.[79]

Wild bison and elk in the greater Yellowstone area are the last remaining reservoir of B. abortus in the US. The recent transmission of brucellosis from elk back to cattle in Idaho and Wyoming illustrates how the area, as the last remaining reservoir in the United States, may adversely affect the livestock industry. Eliminating brucellosis from this area is a challenge, as many viewpoints exist on how to manage diseased wildlife. However, the Wyoming Game and Fish Department has recently begun to protect scavengers (particularly coyotes and red fox) on elk feedgrounds, because they act as sustainable, no-cost, biological control agents by removing infected elk fetuses quickly.[80] Purebred bison in the Henry Mountains of southern Utah are free of brucellosis.[81]

The National Elk Refuge in Jackson, Wyoming asserts that the intensity of the winter feeding program affects the spread of brucellosis more than the population size of elk and bison.[77] Since concentrating animals around food plots accelerates spread of the disease, management strategies to reduce herd density and increase dispersion could limit its spread.[77]

Effects on hunters

Hunters may be at additional risk for exposure to brucellosis due to increased contact with susceptible wildlife, including predators that may have fed on infected prey. Hunting dogs can also be at risk of infection.[82] Exposure can occur through contact with open wounds or by directly inhaling the bacteria while cleaning game.[83] In some cases, consumption of undercooked game can result in exposure to the disease.[83] Hunters can limit exposure while cleaning game through the use of precautionary barriers, including gloves and masks, and by washing tools rigorously after use.[79][84] By ensuring that game is cooked thoroughly, hunters can protect themselves and others from ingesting the disease.[83]

See also

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 Hayoun, MA; Muco, E; Shorman, M (January 2020). "Brucellosis". PMID 28722861. {{cite journal}}: Cite journal requires |journal= (help)
  2. ↑ Griffiths, Jeffrey; Maguire, James H.; Heggenhougen, Kristian; Quah, Stella R. (2010). Public Health and Infectious Diseases. Elsevier. p. 112. ISBN 978-0-12-381507-1. Archived from the original on 2021-08-29. Retrieved 2020-12-17.
  3. ↑ 3.0 3.1 3.2 3.3 "Signs and Symptoms | Brucellosis | CDC". www.cdc.gov. 9 October 2018. Archived from the original on 30 December 2020. Retrieved 17 December 2020.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Brucellosis Reference Guide: Exposures, Testing, and Prevention (PDF). CDC. February 2017. Archived (PDF) from the original on 2020-12-05. Retrieved 2020-12-17.
  5. ↑ 5.0 5.1 5.2 5.3 "Transmission | Brucellosis | CDC". www.cdc.gov. 11 March 2019. Archived from the original on 11 November 2020. Retrieved 17 December 2020.
  6. ↑ 6.0 6.1 Inc, Gideon Informatics; Berger, Dr Stephen (2020). Brucellosis: Global Status. GIDEON Informatics Inc. p. 14. ISBN 978-1-4988-2801-7. Archived from the original on 2021-08-28. Retrieved 2020-12-17.
  7. ↑ "Areas at Risk | Risk of Exposure| Brucellosis | CDC". www.cdc.gov. 17 October 2018. Archived from the original on 24 January 2021. Retrieved 17 December 2020.
  8. ↑ "Соңку жарым жылда Ошто 235 баш мал жана 46 адамдан бруцеллез аныкталды". Turmush (in кыргызча). Archived from the original on 30 July 2022. Retrieved 28 July 2022.
  9. ↑ 9.0 9.1 Galińska, Elżbieta Monika; Zagórski, Jerzy (9 June 2013). "Brucellosis in humans – etiology, diagnostics, clinical forms". Annals of Agricultural and Environmental Medicine. 20 (2): 233–238. ISSN 1232-1966. Archived from the original on 21 April 2021. Retrieved 21 July 2022.
  10. ↑ Sencen, Lisa. "Brucellosis". NORD (National Organization for Rare Disorders). Archived from the original on 10 February 2022. Retrieved 8 August 2022.
  11. ↑ الصحة, فريق بوابة وزارة. "Ministry Of Health Saudi Arabia". Ministry Of Health Saudi Arabia. Archived from the original on 31 July 2022. Retrieved 30 July 2022.
  12. ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 Hayoun, Michael A.; Muco, Erind; Shorman, Mahmoud (2022). "Brucellosis". StatPearls. StatPearls Publishing. Archived from the original on 21 January 2022. Retrieved 16 July 2022.
  13. ↑ Dean, Anna S.; Crump, Lisa; Greter, Helena; Schelling, Esther; Zinsstag, Jakob (25 October 2012). "Global Burden of Human Brucellosis: A Systematic Review of Disease Frequency". PLOS Neglected Tropical Diseases. 6 (10): e1865. doi:10.1371/journal.pntd.0001865. ISSN 1935-2735. Archived from the original on 9 July 2022. Retrieved 3 August 2022.
  14. ↑ Wyatt HV (October 2005). "How Themistocles Zammit found Malta Fever (brucellosis) to be transmitted by the milk of goats". Journal of the Royal Society of Medicine. The Royal Society of Medicine Press. 98 (10): 451–4. doi:10.1177/014107680509801009. OCLC 680110952. PMC 1240100. PMID 16199812.
  15. ↑ Pereira, Carine Rodrigues; Oliveira, Izabela Regina Cardoso; Oliveira, Luciana Faria; Oliveira, Camila Stefanie Fonseca; Lage, Andrey Pereira; Dorneles, Elaine Maria Seles (May 2021). "Accidental exposure to Brucella abortus vaccines and occupational brucellosis among veterinarians in Minas Gerais state, Brazil". Transboundary and Emerging Diseases. 68 (3): 1363–1376. doi:10.1111/tbed.13797. ISSN 1865-1674. Retrieved 31 July 2022.
  16. ↑ Peck ME, Jenpanich C, Amonsin A, Bunpapong N, Chanachai K, Somrongthong R, et al. (January 2019). "Knowledge, Attitudes and Practices Associated with Brucellosis among Small-Scale Goat Farmers in Thailand". Journal of Agromedicine. 24 (1): 56–63. doi:10.1080/1059924X.2018.1538916. PMID 30350754. S2CID 53034163.
  17. ↑ Young, Edward J.; Corbel, Michael J. (24 July 2020). Brucellosis: Clinical and Laboratory Aspects. CRC Press. pp. 35–39. ISBN 978-1-000-14190-0. Archived from the original on 24 July 2022. Retrieved 24 July 2022.
  18. ↑ "Serology | Clinicians | Brucellosis | CDC". www.cdc.gov. 13 June 2019. Archived from the original on 18 June 2022. Retrieved 22 July 2022.
  19. ↑ Yagupsky, Pablo; Morata, Pilar; Colmenero, Juan D. (18 December 2019). "Laboratory Diagnosis of Human Brucellosis". Clinical Microbiology Reviews. 33 (1): e00073–19. doi:10.1128/CMR.00073-19. ISSN 1098-6618. Archived from the original on 15 June 2022. Retrieved 17 July 2022.
  20. ↑ Franco MP, Mulder M, Gilman RH, Smits HL (December 2007). "Human brucellosis". The Lancet. Infectious Diseases. 7 (12): 775–86. doi:10.1016/S1473-3099(07)70286-4. PMID 18045560.
  21. ↑ Al Dahouk S, Nöckler K (July 2011). "Implications of laboratory diagnosis on brucellosis therapy". Expert Review of Anti-Infective Therapy. 9 (7): 833–45. doi:10.1586/eri.11.55. PMID 21810055. S2CID 5068325.
  22. ↑ Wilson, J. D.; Simpson, S. I. (6 December 2012). Diagnostic Immunology and Serology: A Clinicians’ Guide. Springer Science & Business Media. p. 15. ISBN 978-94-015-1126-1. Archived from the original on 19 July 2022. Retrieved 18 July 2022.
  23. ↑ Mantur B, Parande A, Amarnath S, Patil G, Walvekar R, Desai A, et al. (August 2010). "ELISA versus conventional methods of diagnosing endemic brucellosis". The American Journal of Tropical Medicine and Hygiene. 83 (2): 314–8. doi:10.4269/ajtmh.2010.09-0790. PMC 2911177. PMID 20682874.
  24. ↑ Yu WL, Nielsen K (August 2010). "Review of detection of Brucella spp. by polymerase chain reaction". Croatian Medical Journal. 51 (4): 306–13. doi:10.3325/cmj.2010.51.306. PMC 2931435. PMID 20718083.
  25. ↑ Vrioni G, Pappas G, Priavali E, Gartzonika C, Levidiotou S (June 2008). "An eternal microbe: Brucella DNA load persists for years after clinical cure". Clinical Infectious Diseases. 46 (12): e131-6. doi:10.1086/588482. PMID 18462106.
  26. ↑ 26.0 26.1 "Animal and Plant Health Inspection Service-Facts About Brucellosis-". USDA. Archived from the original on 27 July 2021. Retrieved 20 July 2022.
  27. ↑ Malaysia, Bahagian Kawalan Penyakit, Kementerian Kesihatan. MYCDCGP - Guideline For Diagnosis Management Prevention & Control of Human Brucellosis in Malaysia: 1st Edition, 2012. BKPKKM. p. 11. Archived from the original on 19 July 2022. Retrieved 18 July 2022.
  28. ↑ Solera, Javier (November 2010). "Update on brucellosis: therapeutic challenges". International Journal of Antimicrobial Agents. 36 Suppl 1: S18–20. doi:10.1016/j.ijantimicag.2010.06.015. ISSN 1872-7913. Archived from the original on 18 June 2022. Retrieved 20 July 2022.
  29. ↑ Hasanjani Roushan MR, Mohraz M, Hajiahmadi M, Ramzani A, Valayati AA (April 2006). "Efficacy of gentamicin plus doxycycline versus streptomycin plus doxycycline in the treatment of brucellosis in humans". Clinical Infectious Diseases. 42 (8): 1075–80. doi:10.1086/501359. PMID 16575723.
  30. ↑ McLean DR, Russell N, Khan MY (October 1992). "Neurobrucellosis: clinical and therapeutic features". Clinical Infectious Diseases. 15 (4): 582–90. doi:10.1093/clind/15.4.582. PMID 1420670.
  31. ↑ Yousefi-Nooraie R, Mortaz-Hejri S, Mehrani M, Sadeghipour P (October 2012). "Antibiotics for treating human brucellosis". The Cochrane Database of Systematic Reviews. 10: CD007179. doi:10.1002/14651858.cd007179.pub2. PMC 6532606. PMID 23076931.
  32. ↑ Alavi, Seyed Mohammad; Alavi, Leila (2013). "Treatment of brucellosis: a systematic review of studies in recent twenty years". Caspian Journal of Internal Medicine. 4 (2): 636–641. ISSN 2008-6164. Archived from the original on 18 June 2022. Retrieved 21 July 2022.
  33. ↑ Duĭsenova, A. K.; Kurmanova, K. B.; Kurmanova, G. M. (2002). "[Ciprofloxacin in the treatment of patients with brucellosis]". Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [sic]. 47 (10): 3–7. ISSN 0235-2990. Archived from the original on 28 July 2022. Retrieved 25 July 2022.
  34. ↑ Turgut, Mehmet; Haddad, Fuad Sami; Divitiis, Oreste de (18 December 2015). Neurobrucellosis: Clinical, Diagnostic and Therapeutic Features. Springer. p. 138. ISBN 978-3-319-24639-0. Archived from the original on 1 August 2022. Retrieved 1 August 2022.
  35. ↑ 35.0 35.1 Reguera, J. M.; Alarcón, A.; Miralles, F.; Pachón, J.; Juárez, C.; Colmenero, J. D. (November 2003). "Brucella endocarditis: clinical, diagnostic, and therapeutic approach". European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology. 22 (11): 647–650. doi:10.1007/s10096-003-1026-z. ISSN 0934-9723. Archived from the original on 15 June 2022. Retrieved 6 August 2022.
  36. ↑ Shah, Raju C. (31 March 2020). IAP Textbook of Tropical Diseases. Jaypee Brothers Medical Publishers. p. 250. ISBN 978-93-89776-33-1. Archived from the original on 19 July 2022. Retrieved 18 July 2022.
  37. ↑ Yagupsky P, Baron EJ (August 2005). "Laboratory exposures to brucellae and implications for bioterrorism". Emerging Infectious Diseases. 11 (8): 1180–5. doi:10.3201/eid1108.041197. PMC 3320509. PMID 16102304.
  38. ↑ Centers for Disease Control Prevention (CDC) (January 2008). "Laboratory-acquired brucellosis--Indiana and Minnesota, 2006". MMWR. Morbidity and Mortality Weekly Report. 57 (2): 39–42. PMID 18199967.
  39. ↑ Lowe CF, Showler AJ, Perera S, McIntyre S, Qureshi R, Patel SN, et al. (January 2015). "Hospital-associated transmission of Brucella melitensis outside the laboratory". Emerging Infectious Diseases. 21 (1): 150–2. doi:10.3201/eid2101.141247. PMC 4285263. PMID 25531198.
  40. ↑ Ariza, Javier; Bosilkovski, Mile; Cascio, Antonio; Colmenero, Juan D; Corbel, Michael J; Falagas, Matthew E; Memish, Ziad A; Roushan, Mohammad Reza Hasanjani; Rubinstein, Ethan; Sipsas, Nikolaos V; Solera, Javier; Young, Edward J; Pappas, Georgios (27 December 2007). "Perspectives for the Treatment of Brucellosis in the 21st Century: The Ioannina Recommendations". PLOS Medicine. 4 (12): e317. doi:10.1371/journal.pmed.0040317. PMC 2222927. PMID 18162038.
  41. ↑ Samartino LE (December 2002). "Brucellosis in Argentina". Veterinary Microbiology. 90 (1–4): 71–80. doi:10.1016/s0378-1135(02)00247-x. PMID 12414136.
  42. ↑ "SENASA – Direcci n Nacional de Sanidad Animal". viejaweb.senasa.gov.ar. Archived from the original on 2016-02-16. Retrieved 2016-02-10.
  43. ↑ "Queensland Health: Brucellosis". State of Queensland (Queensland Health). 2010-11-24. Archived from the original on 2011-04-22. Retrieved 2011-06-06.
  44. ↑ Lehane, Robert (1996) Beating the Odds in a Big Country: The eradication of bovine brucellosis and tuberculosis in Australia, CSIRO Publishing, ISBN 0-643-05814-1
  45. ↑ "Reportable Diseases". Accredited Veterinarian’s Manual. Canadian Food Inspection Agency. Archived from the original on 2007-02-08. Retrieved 2007-03-18.
  46. ↑ Zheng, Rongjiong; Xie, Songsong; Lu, Xiaobo; Sun, Lihua; Zhou, Yan; Zhang, Yuexin; Wang, Kai (22 April 2018). "A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China". BioMed Research International. 2018: e5712920. doi:10.1155/2018/5712920. ISSN 2314-6133. Archived from the original on 31 July 2022. Retrieved 30 July 2022.
  47. ↑ China reports outbreak of brucellosis disease ‘way larger’ than originally thought Archived 2021-05-24 at the Wayback Machine 18 September 2020 www.news.com.au, accessed 18 September 2020
  48. ↑ "Archive copy". Archived from the original on 2021-05-24. Retrieved 2020-10-04.{{cite web}}: CS1 maint: archived copy as title (link)
  49. ↑ Naudi JR (2005). Brucellosis, The Malta Experience. Malta: Publishers Enterprises group (PEG) Ltd. ISBN 978-99909-0-425-3.
  50. ↑ 50.0 50.1 50.2 "Ireland free of brucellosis". RTÉ. 2009-07-01. Archived from the original on 2009-07-04. Retrieved 2009-07-01.
  51. ↑ 51.0 51.1 51.2 51.3 "Ireland declared free of brucellosis". The Irish Times. 2009-07-01. Archived from the original on 2021-04-03. Retrieved 2009-07-01. Michael F Sexton, president of Veterinary Ireland, which represents vets in practice, said: "Many vets and farmers in particular suffered significantly with brucellosis in past decades and it is greatly welcomed by the veterinary profession that this debilitating disease is no longer the hazard that it once was."
  52. ↑ 52.0 52.1 52.2 Monitoring brucellosis in Great Britain Archived 2020-09-29 at the Wayback Machine 3 September 2020 veterinary-practice.com, accessed 18 September 2020
  53. ↑ Guidance Brucellosis: how to spot and report the disease Archived 2021-04-17 at the Wayback Machine 18 October 2018 www.gov.uk, accessed 18 September 2020
  54. ↑ "MAF Biosecurity New Zealand: Brucellosis". Ministry of Agriculture and Forestry of New Zealand. Archived from the original on 2012-03-20. Retrieved 2011-06-06.
  55. ↑ "Brucellosis: Resources: Surveillance". CDC. 2018-10-09. Archived from the original on 2019-06-23. Retrieved 2017-09-08.
  56. ↑ Brucellosis Eradication APHIS 91–45–013. United States Department of Agriculture. October 2003. p. 14.
  57. ↑ Hamilton AV, Hardy AV (March 1950). "The brucella ring test; its potential value in the control of brucellosis" (PDF). American Journal of Public Health and the Nation's Health. 40 (3): 321–3. doi:10.2105/AJPH.40.3.321. PMC 1528431. PMID 15405523. Archived (PDF) from the original on 2008-12-17. Retrieved 2008-08-27.
  58. ↑ Vermont Beef Producers. "How important is calfhood vaccination?" (PDF). Archived from the original (PDF) on 2008-05-09.
  59. ↑ "National Brucellosis Eradication Program". USDA. Archived from the original on 20 January 2022. Retrieved 22 July 2022.
  60. ↑ Meagher M, Meyer ME (September 1994). "On the Origin of Brucellosis in Bison of Yellowstone National Park: A Review" (PDF). Conservation Biology. 8 (3): 645–653. doi:10.1046/j.1523-1739.1994.08030645.x. JSTOR 2386505. Archived from the original (PDF) on 2017-01-08. Retrieved 2017-01-07.
  61. ↑ Wilkinson L (1993). "Brucellosis". In Kiple KF (ed.). The Cambridge World History of Human Disease. Cambridge University Press.
  62. ↑ Brucellosis named after Major-General Sir David Bruce at Who Named It?
  63. ↑ Williams, T. F.; McKUSICK, V. A. (January 1954). "Bernhard Bang: physician, veterinarian, scientist, 1848-1932". Bulletin of the History of Medicine. 28 (1): 60–72. ISSN 0007-5140. Archived from the original on 24 July 2022. Retrieved 23 July 2022.
  64. ↑ Wyatt HV (2015). "The Strange Case of Temi Zammit's missing experiments" (PDF). Journal of Maltese History. Malta: Department of History, University of Malta. 4 (2): 54–56. ISSN 2077-4338. Archived from the original (PDF) on 2016-07-21. Journal archive
  65. ↑ 65.0 65.1 65.2 65.3 65.4 65.5 65.6 de Kruif P (1932). "Ch. 5 Evans: death in milk". Men Against Death. New York: Harcourt, Brace. OCLC 11210642. Archived from the original on 2021-08-28. Retrieved 2020-11-09.
  66. ↑ 66.0 66.1 Wyatt HV (31 July 2004). "Give A Disease A Bad Name". British Medical Journal. BMJ Publishing Group Ltd. 329 (7460): 272–278. doi:10.1136/bmj.329.7460.272. ISSN 0959-535X. JSTOR 25468794. OCLC 198096808. PMC 498028.
  67. ↑ Malhotra R (2004). "Saudi Arabia". Practical Neurology. 4 (3): 184–185. doi:10.1111/j.1474-7766.2004.03-225.x.
  68. ↑ Al-Sous MW, Bohlega S, Al-Kawi MZ, Alwatban J, McLean DR (March 2004). "Neurobrucellosis: clinical and neuroimaging correlation". AJNR. American Journal of Neuroradiology. 25 (3): 395–401. PMID 15037461. Archived from the original on 2019-10-17. Retrieved 2008-08-27.
  69. ↑ "Medicine: Goat Fever". Time. 1928-12-10. ISSN 0040-781X. Archived from the original on 2019-06-29. Retrieved 2017-05-01.
  70. ↑ Woods, Jon B. (April 2005). USAMRIID's Medical Management of Biological Casualties Handbook (PDF) (6th ed.). Fort Detrick, Maryland: U.S. Army Medical Institute of Infectious Diseases. p. 53. Archived from the original (PDF) on 2007-06-09.
  71. ↑ Roffey, R.; Tegnell, A.; Elgh, F. (1 August 2002). "Biological warfare in a historical perspective". Clinical Microbiology and Infection. 8 (8): 450–454. doi:10.1046/j.1469-0691.2002.00501.x. ISSN 1198-743X. Archived from the original on 26 May 2022. Retrieved 27 July 2022.
  72. ↑ "Brucellosis in animals". www.agric.wa.gov.au. Archived from the original on 13 March 2022. Retrieved 23 July 2022.
  73. ↑ Radostits, O.M., C.C. Gay, D.C. Blood, and K.W. Hinchcliff. (2000). Veterinary Medicine, A textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses. Harcourt Publishers Limited, London, pp. 867–882. ISBN 0702027774.
  74. ↑ "Brucellosis in Cattle - Reproductive System". Merck Veterinary Manual. Archived from the original on 28 October 2021. Retrieved 19 July 2022.
  75. ↑ Ettinger SJ, Feldman EC (1995). Textbook of Veterinary Internal Medicine (4th ed.). W.B. Saunders Company. ISBN 978-0-7216-4679-4.
  76. ↑ Guzmán-Verri C, González-Barrientos R, Hernández-Mora G, Morales JA, Baquero-Calvo E, Chaves-Olarte E, Moreno E (2012). "Brucella ceti and brucellosis in cetaceans". Frontiers in Cellular and Infection Microbiology. 2: 3. doi:10.3389/fcimb.2012.00003. PMC 3417395. PMID 22919595.
  77. ↑ 77.0 77.1 77.2 "Brucellosis". www.fws.gov. U.S. Fish &Wildlife Service. 2016. Archived from the original on 2016-10-09. Retrieved 2016-10-03.
  78. ↑ Godfroid J (August 2002). "Brucellosis in wildlife" (PDF). Revue Scientifique et Technique. 21 (2): 277–86. doi:10.20506/rst.21.2.1333. PMID 11974615. Archived from the original (PDF) on 2015-06-06. Retrieved 2016-10-07.
  79. ↑ 79.0 79.1 79.2 Godfroid J, Garin-Bastuji B, Saegerman C, Blasco JM (April 2013). "Brucellosis in terrestrial wildlife" (PDF). Revue Scientifique et Technique. 32 (1): 27–42. CiteSeerX 10.1.1.1020.9652. doi:10.20506/rst.32.1.2180. PMID 23837363. Archived from the original (PDF) on 2015-06-06. Retrieved 2016-10-07.
  80. ↑ Cross PC, Maichak EJ, Brennan A, Scurlock BM, Henningsen J, Luikart G (April 2013). "An ecological perspective on Brucella abortus in the western United States" (PDF). Revue Scientifique et Technique. 32 (1): 79–87. doi:10.20506/rst.32.1.2184. PMID 23837367. Archived (PDF) from the original on 2016-04-19. Retrieved 2016-06-20.
  81. ↑ Ranglack DH, Dobson LK, du Toit JT, Derr J (December 17, 2015). "Genetic Analysis of the Henry Mountains Bison Herd". PLOS ONE. 10 (12): e0144239. Bibcode:2015PLoSO..1044239R. doi:10.1371/journal.pone.0144239. PMC 4682953. PMID 26673758.
  82. ↑ "CDC - Hunters Risks - Animals That Can Put Hunters at Risk". Archived from the original on 2019-06-23. Retrieved 2019-06-23.
  83. ↑ 83.0 83.1 83.2 "CDC – Home – Brucellosis". www.cdc.gov. Center for Disease Control. 2016. Archived from the original on 2016-10-09. Retrieved 2016-10-03.
  84. ↑ "Zoonoses – Brucellosis". www.who.int/en/. World Health Organization. 2016. Archived from the original on 2016-10-18. Retrieved 2016-10-03.

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