|A Brenner tumor of ovary (gross image).|
|Types||Borderline, malignantis a type of ovarian tumor.|
On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumours can vary in size from less than 1 centimetre (0.39 in) to 30 centimetres (12 in). Borderline and malignant Brenner tumours are possible but each are rare.
Also recall that the "coffee bean nuclei" are the nuclear grooves exceptionally pathognomonic to the sex cord stromal tumor, the ovarian granulosa cell tumor, with the fluid-filled spaces Call–Exner bodies between the granulosa cells.
Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour.
Histologically, Leydig cell tumors of the testes and ovarian stromal Leydig cell tumors (ovarian hyperandrogenism and virilization) both have characteristic Reinke crystals. The same crystals were also noted under high power view in Brenner tumors.
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