|A CT of the head years after a traumatic brain injury showing an empty space where the damage occurred, marked by the arrow|
Neurotrauma, brain damage or brain injury (BI) is the destruction or degeneration of brain cells. Brain injuries occur due to a wide range of internal and external factors. In general, brain damage refers to significant, undiscriminating trauma-induced damage.
A common category with the greatest number of injuries is traumatic brain injury (TBI) following physical trauma or head injury from an outside source, and the term acquired brain injury (ABI) is used in appropriate circles to differentiate brain injuries occurring after birth from injury, from a genetic disorder (GBI), or from a congenital disorder (CBI). Primary and secondary brain injuries identify the processes involved, while focal and diffuse brain injury describe the severity and localization.
Recent research has demonstrated that neuroplasticity, which allows the brain to reorganize itself by forming new neural connections throughout life, provides for rearrangement of its workings. This allows the brain to compensate for injury and disease.
Signs and symptoms
Symptoms of brain injuries vary based on the severity of the injury or how much of the brain is affected. The three categories used for classifying the severity of brain injuries are mild, moderate or severe.
Severity of injuries
Mild brain injuries
Symptoms of a mild brain injury include headaches, confusions, tinnitus, fatigue, changes in sleep patterns, mood or behavior. Other symptoms include trouble with memory, concentration, attention or thinking. Mental fatigue is a common debilitating experience and may not be linked by the patient to the original (minor) incident.
Moderate/severe brain injuries
Cognitive symptoms include confusion, aggressiveness, abnormal behavior, slurred speech, and coma or other disorders of consciousness. Physical symptoms include headaches that worsen or do not go away, vomiting or nausea, convulsions, abnormal dilation of the eyes, inability to awaken from sleep, weakness in extremities and loss of coordination.
Symptoms in children
Symptoms observed in children include changes in eating habits, persistent irritability or sadness, changes in attention, or disrupted sleeping habits.
Location of brain damage predicts symptoms
Symptoms of brain injuries can also be influenced by the location of the injury and as a result impairments are specific to the part of the brain affected. Lesion size is correlated with severity, recovery, and comprehension. Brain injuries often create impairment or disability that can vary greatly in severity.
In cases of severe brain injuries, the likelihood of areas with permanent disability is great, including neurocognitive deficits, delusions (often, to be specific, monothematic delusions), speech or movement problems, and intellectual disability. There may also be personality changes. The most severe cases result in coma or even persistent vegetative state. Even a mild incident can have long-term effects or cause symptoms to appear years later.
Studies show there is a correlation between brain lesion and language, speech, and category-specific disorders. Wernicke's aphasia is associated with anomia, unknowingly making up words (neologisms), and problems with comprehension. The symptoms of Wernicke’s aphasia are caused by damage to the posterior section of the superior temporal gyrus.
Damage to the Broca’s area typically produces symptoms like omitting functional words (agrammatism), sound production changes, dyslexia, dysgraphia, and problems with comprehension and production. Broca’s aphasia is indicative of damage to the posterior inferior frontal gyrus of the brain.
An impairment following damage to a region of the brain does not necessarily imply that the damaged area is wholly responsible for the cognitive process which is impaired, however. For example, in pure alexia, the ability to read is destroyed by a lesion damaging both the left visual field and the connection between the right visual field and the language areas (Broca's area and Wernicke's area). However, this does not mean one suffering from pure alexia is incapable of comprehending speech—merely that there is no connection between their working visual cortex and language areas—as is demonstrated by the fact that pure alexics can still write, speak, and even transcribe letters without understanding their meaning.
Lesions to the fusiform gyrus often result in prosopagnosia, the inability to distinguish faces and other complex objects from each other. Lesions in the amygdala would eliminate the enhanced activation seen in occipital and fusiform visual areas in response to fear with the area intact. Amygdala lesions change the functional pattern of activation to emotional stimuli in regions that are distant from the amygdala.
Other lesions to the visual cortex have different effects depending on the location of the damage. Lesions to V1, for example, can cause blindsight in different areas of the brain depending on the size of the lesion and location relative to the calcarine fissure. Lesions to V4 can cause color-blindness, and bilateral lesions to MT/V5 can cause the loss of the ability to perceive motion. Lesions to the parietal lobes may result in agnosia, an inability to recognize complex objects, smells, or shapes, or amorphosynthesis, a loss of perception on the opposite side of the body.
Brain injuries have far-reaching and varied consequences due to the nature of the brain as the main source of bodily control. Brain-injured people commonly experience issues with memory. This can be issues with either long or short-term memories depending on the location and severity of the injury. Sometimes memory can be improved through rehabilitation, although it can be permanent. Behavioral and personality changes are also commonly observed due to changes of the brain structure in areas controlling hormones or major emotions. Headaches and pain can also occur as a result of a brain injury either directly from the damage or due to neurological conditions stemming from the injury. Due to the changes in the brain as well as the issues associated with the change in physical and mental capacity, depression and low self-esteem are common side effects that can be treated with psychological help. Antidepressants must be used with caution in brain injury people due to the potential for undesired effects because of the already altered brain chemistry.
Long term psychological and physiological effects
There are multiple responses of the body to brain injury, occurring at different times after the initial occurrence of damage, as the functions of the neurons, nerve tracts, or sections of the brain can be affected by damage. The immediate response can take many forms. Initially, there may be symptoms such as swelling, pain, bruising, or loss of consciousness. Post-traumatic amnesia is also common with brain damage, as is temporary aphasia, or impairment of language.
As time progresses, and the severity of injury becomes clear, there are further responses that may become apparent. Due to loss of blood flow or damaged tissue, sustained during the injury, amnesia and aphasia may become permanent, and apraxia has been documented in patients. Amnesia is a condition in which a person is unable to remember things. Aphasia is the loss or impairment of word comprehension or use. Apraxia is a motor disorder caused by damage to the brain, and may be more common in those who have been left brain damaged, with loss of mechanical knowledge critical. Headaches, occasional dizziness, and fatigue—all temporary symptoms of brain trauma—may become permanent, or may not disappear for a long time.
There are documented cases of lasting psychological effects as well, such as emotional changes often caused by damage to the various parts of the brain that control human emotions and behavior. Individuals who have experienced emotional changes related to brain damage may have emotions that come very quickly and are very intense, but have very little lasting effect. Emotional changes may not be triggered by a specific event, and can be a cause of stress to the injured party and their family and friends. Often, counseling is suggested for those who experience this effect after their injury, and may be available as an individual or group session.
It is important to note that the long term psychological and physiological effects will vary by person and injury. For example, perinatal brain damage has been implicated in cases of neurodevelopmental impairments and psychiatric illnesses. If any concerning symptoms, signs, or changes to behaviors are occurring, a healthcare provider should be consulted.
Brain injuries can result from a number of conditions, including:
- trauma; multiple traumatic injuries can lead to chronic traumatic encephalopathy. A coup-contrecoup injury occurs when the force impacting the head is not only strong enough to cause a contusion at the site of impact, but also able to move the brain and cause it to displace rapidly into the opposite side of the skull, causing an additional contusion.
- deceleration injuries
- poisoning; for example, from heavy metals including mercury and compounds of lead
- Genetic disorder
- hypoxia, including birth hypoxia
- stroke leading to infarct, which may follow thrombosis, embolisms, angiomas, aneurysms, and cerebral arteriosclerosis.
- neurological illness or disorders such as cerebral palsy, Parkinson's disease, etc
- Substance use disorder
- neurotoxins- pollution exposure or biological exposure (Annonaceae, rotenone, Aspergillus spores, West Nile fever, Viral meningitis)
- failed suicide attempt such as hanging, falling off from height, and even on rare occasion getting shot by a firearm, etc.
Chemotherapy can cause brain damage to the neural stem cells and oligodendrocyte cells that produce myelin. Radiation and chemotherapy can lead to brain tissue damage by disrupting or stopping blood flow to the affected areas of the brain. This damage can cause long term effects such as but not limited to; memory loss, confusion, and loss of cognitive function. The brain damage caused by radiation depends on where the brain tumor is located, the amount of radiation used, and the duration of the treatment. Radiosurgery can also lead to tissue damage that results in about 1 in 20 patients requiring a second operation to remove the damaged tissue.
Wernicke–Korsakoff syndrome can cause brain damage and results from a Vitamin B deficiency. This syndrome presents with two conditions, Wernicke’s encephalopathy and Korsakoff psychosis. Typically Wernicke’s encephalopathy precedes symptoms of Korsakoff psychosis. Wernicke’s encephalopathy causes bleeding in the thalamus or hypothalamus, which controls the nervous and endocrine system. Due to the bleeding, brain damage occurs causing problems with vision, coordination, and balance. Korsakoff psychosis typically follows after the symptoms of Wernicke’s decrease and result from chronic brain damage. Korsakoff psychosis affect memory. Wernicke-Korsakoff syndrome is typically caused by chronic heavy alcohol use or by conditions that affect nutritional absorption, including colon cancer, eating disorders and gastric bypass.
Brain lesions are sometimes intentionally inflicted during neurosurgery, such as the carefully placed brain lesion used to treat epilepsy and other brain disorders. These lesions are induced by excision or by electric shocks (electrolytic lesions) to the exposed brain or commonly by infusion of excitotoxins to specific areas.
Diffuse axonal injury is caused by shearing forces on the brain leading to lesions in the white matter tracts of the brain. These shearing forces are seen in cases where the brain had a sharp rotational acceleration, and is caused by the difference in density between white matter and grey matter.
Body's response to brain injury
Unlike some of the more obvious responses to brain damage, the body also has invisible physical responses which can be difficult to notice. These will generally be identified by a healthcare provider, especially as they are normal physical responses to brain damage. Cytokines are known to be induced in response to brain injury. These have diverse actions that can cause, exacerbate, mediate and/or inhibit cellular injury and repair. TGFβ seems to exert primarily neuroprotective actions, whereas TNFα might contribute to neuronal injury and exert protective effects. IL-1 mediates ischaemic, excitotoxic, and traumatic brain injury, probably through multiple actions on glia, neurons, and the vasculature. Cytokines may be useful in order to discover novel therapeutic strategies. At the current time, they are already in clinical trials.
Glasgow Coma Scale (GCS) is the most widely used scoring system used to assess the level of severity of a brain injury. This method is based on the objective observations of specific traits to determine the severity of a brain injury. It is based on three traits: eye opening, verbal response, and motor response, gauged as described below. Based on the Glasgow Coma Scale severity is classified as follows, severe brain injuries score 3–8, moderate brain injuries score 9–12 and mild score 13–15.
There are several imaging techniques that can aid in diagnosing and assessing the extent of brain damage, such as computed tomography (CT) scan, magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) magnetic resonance spectroscopy (MRS), positron emission tomography (PET), and single-photon emission tomography (SPECT). CT scans and MRI are the two techniques widely used and are most effective. CT scans can show brain bleeds, fractures of the skull, fluid build up in the brain that will lead to increased cranial pressure. MRI is able to better to detect smaller injuries, detect damage within the brain, diffuse axonal injury, injuries to the brainstem, posterior fossa, and subtemporal and subfrontal regions. However, patients with pacemakers, metallic implants, or other metal within their bodies are unable to have an MRI done. Typically the other imaging techniques are not used in a clinical setting because of the cost, lack of availability.
The treatment for emergency traumatic brain injuries focuses on assuring the person has enough oxygen from the brain blood supply, and on maintaining normal blood pressure to avoid further injuries of the head or neck. The person may need surgery to remove clotted blood or repair skull fractures, for which cutting a hole in the skull may be necessary. Medicines used for traumatic injuries are diuretics, anti-seizure or coma-inducing drugs. Diuretics reduce the fluid in tissues lowering the pressure on the brain. In the first week after a traumatic brain injury, a person may have a risk of seizures, which anti-seizure drugs help prevent. Coma-inducing drugs may be used during surgery to reduce impairments and restore blood flow.
Various professions may be involved in the medical care and rehabilitation of someone suffering impairment after a brain injury. Neurologists, neurosurgeons, and physiatrists are physicians specialising in treating brain injury. Neuropsychologists (especially clinical neuropsychologists) are psychologists specialising in understanding the effects of brain injury and may be involved in assessing the severity or creating rehabilitation strategies. Occupational therapists may be involved in running rehabilitation programs to help restore lost function or help re-learn essential skills. Registered nurses, such as those working in hospital intensive care units, are able to maintain the health of the severely brain-injured with constant administration of medication and neurological monitoring, including the use of the Glasgow Coma Scale used by other health professionals to quantify extent of orientation.
Physiotherapists also play a significant role in rehabilitation after a brain injury. In the case of a traumatic brain injury (TBIs), physiotherapy treatment during the post-acute phase may include sensory stimulation, serial casting and splinting, fitness and aerobic training, and functional training. Sensory stimulation refers to regaining sensory perception through the use of modalities. There is no evidence to support the efficacy of this intervention. Serial casting and splinting are often used to reduce soft tissue contractures and muscle tone. Evidence based research reveals that serial casting can be used to increase passive range of motion (PROM) and decrease spasticity. Studies also report that fitness and aerobic training will increase cardiovascular fitness; however the benefits will not be transferred to the functional level. Functional training may also be used to treat patients with TBIs. To date, no studies supports the efficacy of sit to stand training, arm ability training and body weight support systems (BWS). Overall, studies suggest that patients with TBIs who participate in more intense rehabilitation programs will see greater benefits in functional skills. More research is required to better understand the efficacy of the treatments mentioned above.
Prognosis, or the likely progress of a disorder, depends on the nature, location, and cause of the brain damage (see Traumatic brain injury, Focal and diffuse brain injury, Primary and secondary brain injury).
In general, neuroregeneration can occur in the peripheral nervous system but is much rarer and more difficult to assist in the central nervous system (brain or spinal cord). However, in neural development in humans, areas of the brain can learn to compensate for other damaged areas, and may increase in size and complexity and even change function, just as someone who loses a sense may gain increased acuity in another sense—a process termed neuroplasticity.
There are many misconceptions that revolve around brain injuries and brain damage. One misconception is that if someone has brain damage then they cannot fully recover. Recovery depends a variety of factors; such as severity and location. Testing is done to note severity and location. Not everyone fully heals from brain damage, but it is possible to have a full recovery. Brain injuries are very hard to predict in outcome. Many tests and specialists are needed to determine the likelihood of the prognosis. People with minor brain damage can have debilitating side effects; not just severe brain damage has debilitating effects. The side-effects of a brain injury depend on location and the body’s response to injury. Even a mild concussion can have long term effects that may not resolve. Another misconception is that children heal better from brain damage. Children are at greater risk for injury due to lack of maturity. It makes future development hard to predict.[dead link] This is because different cortical areas mature at different stages, with some major cell populations and their corresponding cognitive faculties remaining unrefined until early adulthood. In the case of a child with frontal brain injury, for example, the impact of the damage may be undetectable until that child fails to develop normal executive functions in his or her late teens and early twenties.
The foundation for understanding human behavior and brain injury can be attributed to the case of Phineas Gage and the famous case studies by Paul Broca. The first case study on Phineas Gage’s head injury is one of the most astonishing brain injuries in history. In 1848, Phineas Gage was paving way for a new railroad line when he encountered an accidental explosion of a tamping iron straight through his frontal lobe. Gage observed to be intellectually unaffected but exemplified post injury behavioral deficits. These deficits include: becoming sporadic, disrespectful, extremely profane, and gave no regard for other workers. Gage started having seizures in February, dying only four months later on May 21, 1860.
Ten years later, Paul Broca examined two patients exhibiting impaired speech due to frontal lobe injuries. Broca’s first patient lacked productive speech. He saw this as an opportunity to address language localization. It was not until Leborgne, informally known as "tan", died when Broca confirmed the frontal lobe lesion from an autopsy. The second patient had similar speech impairments, supporting his findings on language localization. The results of both cases became a vital verification of the relationship between speech and the left cerebral hemisphere. The affected areas are known today as Broca’s area and Broca’s Aphasia.
A few years later, a German neuroscientist, Carl Wernicke, consulted on a stroke patient. The patient experienced neither speech nor hearing impairments, but suffered from a few brain deficits. These deficits included: lacking the ability to comprehend what was spoken to him and the words written down. After his death, Wernicke examined his autopsy that found a lesion located in the left temporal region. This area became known as Wernicke's area. Wernicke later hypothesized the relationship between Wernicke's area and Broca's area, which was proven fact.
- Cerebral palsy
- Fetal alcohol spectrum disorder
- Frontal lobe injury
- Head injury
- "What is an Acquired Brain Injury?" (PDF). Headway. Archived from the original (PDF) on 2016-07-05. Retrieved 19 September 2016.
- "Traumatic Brain Injury Information Page: National Institute of Neurological Disorders and Stroke (NINDS)". www.ninds.nih.gov. Archived from the original on 2018-11-10. Retrieved 2018-11-09.
- "Traumatic brain injury Symptoms – Mayo Clinic". www.mayoclinic.org. Archived from the original on 2016-11-15. Retrieved 2016-11-15.
- Stefaniak, James D.; Halai, Ajay D.; Lambon Ralph, Matthew A. (2019). "The neural and neurocomputational bases of recovery from post-stroke aphasia". Nature Reviews Neurology. 16 (1): 43–55. doi:10.1038/s41582-019-0282-1. ISSN 1759-4766. PMID 31772339. S2CID 208302688.
- "Traumatic Brain Injury Signs and Symptoms". BrainLine. 2017-12-01. Archived from the original on 2020-04-26. Retrieved 2020-01-23.
- "Superior Temporal Gyrus :: DNA Learning Center". www.dnalc.org. Archived from the original on 2016-12-20. Retrieved 2016-12-09.
- "Wernicke's Aphasia". National Aphasia Association. Archived from the original on 2020-05-22. Retrieved 2016-12-09.
- Kean, Mary Louise. "Broca's and Wernicke's Aphasia". www-rohan.sdsu.edu. Archived from the original on 2017-01-04. Retrieved 2016-12-09.
- More Brain Lesions, Kathleen V. Wilkes
- Purves, Dale; Augustine, George J.; Fitzpatrick, David; Katz, Lawrence C.; LaMantia, Anthony-Samuel; McNamara, James O.; Williams, S. Mark (2001). "Lesions of the Temporal Association Cortex: Deficits of Recognition". Neuroscience. 2nd Edition. Archived from the original on 2022-05-15. Retrieved 2022-05-09.
- Diano, Matteo; Celeghin, Alessia; Bagnis, Arianna; Tamietto, Marco (2017). "Amygdala Response to Emotional Stimuli without Awareness: Facts and Interpretations". Frontiers in Psychology. 7: 2029. doi:10.3389/fpsyg.2016.02029. ISSN 1664-1078. PMC 5222876. PMID 28119645.
- Celesia, Gastone G. (2010-01-01). "Visual Perception and Awareness". Journal of Psychophysiology. 24 (2): 62–67. doi:10.1027/0269-8803/a000014. ISSN 0269-8803.
- Jaeger, W.; Krastel, H.; Braun, St. (1988-12-01). "Cerebrale Achromatopsie (Symptomatik, Verlauf, Differentialdiagnose und Strategie der Untersuchung)". Klinische Monatsblätter für Augenheilkunde (in Deutsch). 193 (12): 627–34. doi:10.1055/s-2008-1050309. ISSN 0023-2165. PMID 3265459.
- Denny-Brown, D., and Betty Q. Banker. "Amorphosynthesis from Left Parietal Lesion". A.M.A. Archives of Neurology and Psychiatry 71, no. 3 (March 1954): 302–13.
- Vakil, Eli (2005-11-01). "The Effect of Moderate to Severe Traumatic Brain Injury (TBI) on Different Aspects of Memory: A Selective Review". Journal of Clinical and Experimental Neuropsychology. 27 (8): 977–1021. doi:10.1080/13803390490919245. ISSN 1380-3395. PMID 16207622. S2CID 17967490.
- "What Happens Immediately After the Injury?". 2008-07-25. Archived from the original on 2016-11-12. Retrieved 2016-11-12.
- "Aphasia Definitions". National Aphasia Association. Archived from the original on 2016-11-09. Retrieved 2016-11-12.
- "Definition of Amnesia". www.merriam-webster.com. Archived from the original on 2016-11-12. Retrieved 2016-11-12.
- Baumard, Josselin; Osiurak, François; Lesourd, Mathieu; Le Gall, Didier (2014-01-01). "Tool use disorders after left brain damage". Frontiers in Psychology. 5: 473. doi:10.3389/fpsyg.2014.00473. PMC 4033127. PMID 24904487.
- "Emotional Problems After Traumatic Brain Injury". www.msktc.org. Archived from the original on 2016-11-11. Retrieved 2016-11-12.
- Währborg, Peter (1991). Assessment & Management of Emotional Reactions to Brain Damage & Aphasia. Far Communications Ltd.
- "TBI: Causes of Traumatic Brain Injury". www.traumaticbraininjury.com. Archived from the original on 2016-11-15. Retrieved 2016-11-15.
- "Birth Hypoxia and Brain Damage to Newborns". Michael E. Duffy. Archived from the original on 2013-08-05. Retrieved 2013-07-27.
- "Overview of Brain Dysfunction – Brain, Spinal Cord, and Nerve Disorders". Merck Manuals Consumer Version. Archived from the original on 2018-07-30. Retrieved 2016-12-09.
- Pamies, David; Block, Katharina; Lau, Pierre; Gribaldo, Laura; Pardo, Carlos A.; Barreras, Paula; Smirnova, Lena; Wiersma, Daphne; Zhao, Liang; Harris, Georgina; Hartung, Thomas (2018-09-01). "Rotenone exerts developmental neurotoxicity in a human brain spheroid model". Toxicology and Applied Pharmacology. 354: 101–14. doi:10.1016/j.taap.2018.02.003. ISSN 0041-008X. PMC 6082736. PMID 29428530.
- Prevention, Cancer Resources from OncoLink | Treatment, Research, Coping, Clinical Trials. "Possible Side Effects of Radiation Treatment for Brain Tumors | OncoLink". www.oncolink.org. Archived from the original on 2016-09-23. Retrieved 2016-09-22.
- "Long Term Side Effects of Brain Tumour Radiotherapy". Cancer Research UK. October 22, 2015. Archived from the original on September 23, 2016. Retrieved September 22, 2016.
- "Wernicke-Korsakoff syndrome: MedlinePlus Medical Encyclopedia". medlineplus.gov. Archived from the original on 2016-07-04. Retrieved 2016-11-15.
- "Wernicke-Korsakoff Syndrome". Healthline. Archived from the original on 2016-11-15. Retrieved 2016-11-15.
- Glenn, Lehmann, Mumby, Woodside. "Differential Fos Expression Following Aspiration, Electrolytic, or Excitotoxic Lesions of the Perirhinal Cortex in Rats Archived 2022-05-15 at the Wayback Machine"
- Vieira RC, Paiva WS, de Oliveira DV, Teixeira MJ, de Andrade AF, de Sousa RM (2016-10-20). "Diffuse Axonal Injury: Epidemiology, Outcome and Associated Risk Factors". Frontiers in Neurology. 7: 178. doi:10.3389/fneur.2016.00178. PMC 5071911. PMID 27812349.
- Gaillard F. "Diffuse axonal injury". radiopaedia.org. Radiopaedia. Archived from the original on 2018-01-08. Retrieved 2018-01-07.
- Dammann, Olaf; O’Shea, Michael (2016-11-12). "Cytokines and Perinatal Brain Damage". Clinics in Perinatology. 35 (4): 643–v. doi:10.1016/j.clp.2008.07.011. ISSN 0095-5108. PMC 3657129. PMID 19026332.
- Zhang, Jun-Ming; An, Jianxiong (2007-01-01). "Cytokines, Inflammation and Pain". International Anesthesiology Clinics. 45 (2): 27–37. doi:10.1097/AIA.0b013e318034194e. ISSN 0020-5907. PMC 2785020. PMID 17426506.
- "What Is the Glasgow Coma Scale?". Archived from the original on 2016-11-15. Retrieved 2016-11-15.
- Watanabe, Thomas; Marino, Michael (2014). Current Diagnosis & Treatment: Physical Medicine & Rehabilitation. McGraw-Hill Education. ISBN 978-0-07-179329-2 – via Access Medicine.[page needed]
- Alderson, P.; Roberts, I. (1997). "Corticosteroids in acute traumatic brain injury: systematic review of randomised controlled trials". BMJ. 314 (7098): 1855–59. doi:10.1136/bmj.314.7098.1855. PMC 2126994. PMID 9224126.
- "Glasgow Coma Scale: Technique and Interpretation". www.clinicsinsurgery.com. Archived from the original on 2020-01-16. Retrieved 2020-01-23.
- Hellweg, Stephanie; Johannes, Stonke (February 2008). "Physiotherapy after traumatic brain injury: A systematic review of the literature". Brain Injury. 22 (5): 365–73. doi:10.1080/02699050801998250. PMID 18415716. S2CID 13374136.
- Watson, Martin (2001). "Do patients with severe traumatic brain injury benefit from physiotherapy? A review of the evidence". Physical Therapy Reviews. 6 (4): 233–49. doi:10.1179/ptr.2001.6.4.233. S2CID 71247575.
- Turner-Stokes, L; Disler, P.; Nair, A.; Wade, T. (2005). "Multidisciplinary rehabilitation for acquired brain injury in adults of working age". Cochrane Database of Systematic Reviews. 3 (3): 1–45. doi:10.1002/14651858.CD004170.pub2. PMID 16034923.
- Canning, C; Shepherd, R.; Carr, J.; Alison, J.; Wade, L.; White, A. (2003). "A randomized controlled trial of the effects of intensive sit-to-stand training after recent traumatic brain injury on sit-to-stand performance". Clinical Rehabilitation. 17 (4): 355–62. doi:10.1191/0269215503cr620oa. PMID 12785242. S2CID 36841611.
- Wilson, D; Powell, M.; Gorham, J.; Childers, M. (2006). "Ambulation training with or without partial weightbearing after traumatic brain injury: Results of a controlled trial". American Journal of Physical Medicine & Rehabilitation. 85 (1): 68–74. doi:10.1097/01.phm.0000193507.28759.37. PMID 16357551. S2CID 44957954.
- Barman, Apurba; Chatterjee, Ahana; Bhide, Rohit (2016). "Cognitive Impairment and Rehabilitation Strategies After Traumatic Brain Injury". Indian Journal of Psychological Medicine. 38 (3): 172–81. doi:10.4103/0253-7176.183086. ISSN 0253-7176. PMC 4904751. PMID 27335510.
- Schmidt, Adam T.; Holland, Jessica N. (2015). "Static and Dynamic Factors Promoting Resilience following Traumatic Brain Injury: A Brief Review". Neural Plasticity. 2015: 902802. doi:10.1155/2015/902802. PMC 4539485. PMID 26347352.
- Holtz, Pamela (2015-06-09). "10 Myths About Traumatic Brain Injury". Task & Purpose. Archived from the original on 2016-08-02. Retrieved 2016-12-09.
- "Myths & Facts About TBI". cbirt.org. Archived from the original on 2016-11-27. Retrieved 2016-12-09.
- Li, Linda; Liu, Jianghong (2013). "The effect of pediatric traumatic brain injury on behavioral outcomes: a systematic review". Developmental Medicine & Child Neurology. 55 (1): 37–45. doi:10.1111/j.1469-8749.2012.04414.x. ISSN 1469-8749. PMC 3593091. PMID 22998525.
- Haas L. F. (2001). "Phineas Gage and the Science of Brain Localisation". Journal of Neurology, Neurosurgery, and Psychiatry. 71 (6): 761. doi:10.1136/jnnp.71.6.761. PMC 1737620. PMID 11723197.
- Dronkers, N. F., O. Plaisant, M. T. Iba-Zizen, and E. A. Cabanis. "Paul Broca's Historic Cases: High Resolution MR Imaging of the Brains of Leborgne and Lelong Archived 2021-11-18 at the Wayback Machine." Brain : A Journal of Neurology 130.5 (2007): 1432–41. Web. 31 Oct. 2016.
- Guenther, Katja (2013-11-01). "The Disappearing Lesion: Sigmund Freud, Sensory-Motor Physiology, and the Beginnings of Psychoanalysis". Modern Intellectual History. 10 (3): 569–601. doi:10.1017/S147924431300022X. ISSN 1479-2443. S2CID 16372696. Archived from the original on 2019-11-01. Retrieved 2022-05-09.
- Sam Kean (2015). The Tale of the Dueling Neurosurgeons: The History of the Human Brain as Revealed by True Stories of Trauma, Madness, and Recovery. Back Bay Books. ISBN 978-0316182355.
|Look up brain damage in Wiktionary, the free dictionary.|