|Source||Humanized (from mouse)|
|Target||Proprotein convertase subtilisin/kexin type 9 (PCSK9)|
|Chemical and physical data|
|Molar mass||145077.18 g·mol−1|
Bococizumab (USAN; development code RN316) is a drug that was in development by Pfizer targeting PCSK9 to reduce LDL cholesterol. Pfizer withdrew the drug from development in November 2016, determining that it was "not likely to provide value to patients, physicians or shareholders."
The Phase 3 SPIRE trials were dose-finding studies and found bococizumab to significantly reduce LDL cholesterol levels, but was commonly associated with anti-drug antibodies. The development of anti-drug antibodies with bococizumab led to an attenuation in LDL lowering at 52 weeks. Wide variation in the relative reduction in cholesterol levels was additionally observed among those not developing antidrug antibodies.  After assessing the data, Pfizer abandoned further development of bococizumab. 
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- World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 110" (PDF). WHO Drug Information. 27 (4).
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- Ridker, Paul (2017). "Lipid-Reduction Variability and AntidrugAntibody Formation with Bococizumab". The New England Journal of Medicine. 376 (16): 1517–1526. doi:10.1056/NEJMoa1614062. PMID 28304227. S2CID 205101298. Retrieved 24 September 2020.
- Adams, Ben. "Pfizer dumps PCSK9 inhibitor bococizumab after finding 'no value' in drug". Fierce Biotech. Questex. Retrieved 24 September 2020.