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A bioptome is a small pincer-shaped cutting/grasping instrument used in medicine for taking endomyocardial biopsy specimens of the heart muscle following heart transplantation in rejection monitoring and for diagnosing some diseases of the heart.[1]

It is flexible and usually operated under the guidance of fluoroscopy or echocardiography.[1]

Since 1962, many modifications to the device and techniques in its use have been made.[2][3]



  1. 1.0 1.1 Baim, Donald S. (2006). Grossman's Cardiac Catheterization, Angiography, and Intervention. Lippincott Williams & Wilkins. p. 396. ISBN 9780781755672. Archived from the original on 2021-01-20. Retrieved 2021-01-01.
  2. Asher, Alex (July 2017). "A review of endomyocardial biopsy and current practice in England: out of date or underutilised?". The British Journal of Cardiology. Archived from the original on 25 October 2020. Retrieved 29 September 2018.
  3. Melvin, Kenneth R.; Mason, Jay W. (15 June 1982). "Endomyocardial biopsy: its history, techniques and current indications". Canadian Medical Association Journal. 126 (12): 1381–1386. ISSN 0008-4409. PMC 1863164. PMID 7044509.
  4. Unterberg-Buchwald, Christina; Ritter, Christian Oliver; Reupke, Verena; Wilke, Robin Niklas; Stadelmann, Christine; Steinmetz, Michael; Schuster, Andreas; Hasenfuß, Gerd; Lotz, Joachim; Uecker, Martin (19 April 2017). "Targeted endomyocardial biopsy guided by real-time cardiovascular magnetic resonance". Journal of Cardiovascular Magnetic Resonance. 19: 45. doi:10.1186/s12968-017-0357-3. ISSN 1097-6647. PMID 28424090. Archived from the original on 24 January 2022. Retrieved 24 January 2022.