Autophagy-related protein 13

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ATG13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesATG13, KIAA0652, PARATARG8, autophagy related 13
External IDsOMIM: 615088 MGI: 1196429 HomoloGene: 32229 GeneCards: ATG13
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 11: 46.62 – 46.67 MbChr 2: 91.5 – 91.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene.[5]

ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.[6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175224 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027244 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: KIAA0652".
  6. ^ Mercer CA, Kaliappan A, Dennis PB (July 2009). "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy". Autophagy. 5 (5): 649–62. doi:10.4161/auto.5.5.8249. PMID 19287211.
  7. ^ Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy". Mol. Biol. Cell. 20 (7): 1981–91. doi:10.1091/mbc.E08-12-1248. PMC 2663915. PMID 19211835.
  8. ^ Chan EY, Longatti A, McKnight NC, Tooze SA (January 2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.

External links

Further reading