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Combination of
AtenololBeta blocker
Trade namesTenoretic, Tenoret, others
Clinical data
Routes of
By mouth
Defined daily dosenot established[1]
External links
AHFS/Drugs.comFDA Professional Drug Information
License data
Legal status

Atenolol/chlorthalidone, also known as co-tenidone, is a combination medication used to treat high blood pressure.[3][4] It is made up of atenolol, a beta-blocker and chlortalidone, a diuretic.[5] It is not recommended as an initial treatment but may be used in those who are taking atenolol and chlortalidone individually.[6] It is taken by mouth.[3]

Common side effects include gastrointestinal upset and gout.[4] Serious side effects may include liver problems, pancreatitis, and psychosis.[4] Use is not recommended during pregnancy.[4] Use during breastfeeding may harm the baby.[3] Atenolol works by blocking β1-adrenergic receptors in the heart, thus decreasing the heart rate and workload.[4] Chlorthalidone works by increasing the amount of sodium lost by the kidneys.[3]

The combination was approved for medical use in the United States in 1984.[5] It is available as a generic medication.[4]


The defined daily dose is not established.[1]

Society and culture


A month supply in the United Kingdom costs the NHS less than 2 £ as of 2019.[4] In the United States the wholesale cost of this amount is about US$12.30.[7] In 2017, it was the 295th most commonly prescribed medication in the United States, with more than one million prescriptions.[8][9]


  1. 1.0 1.1 "WHOCC - ATC/DDD Index". Retrieved 9 September 2020.
  2. "Tenoret 50 mg/12.5 mg film coated tablets - Summary of Product Characteristics (SmPC)". (emc). 29 November 2019. Retrieved 4 May 2020.
  3. 3.0 3.1 3.2 3.3 "DailyMed - atenolol and chlorthalidone tablet". Retrieved 18 April 2019.
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 153. ISBN 9780857113382.
  5. 5.0 5.1 "Atenolol and Chlorthalidone Tablets - FDA prescribing information, side effects and uses". Retrieved 18 April 2019.
  6. "Atenolol Monograph for Professionals". American Society of Health-System Pharmacists. Retrieved 18 April 2019.
  7. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  8. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  9. "Atenolol; Chlorthalidone - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

External links