AsponA antisense RNA
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| AsponA antisense RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of AsponA antisense RNA | |
| Identifiers | |
| Rfam | RF02812 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0046677 |
| SO | SO:0000077,SO:0000370 |
| PDB structures | PDBe |
AsponA is a small asRNA transcribed antisense to the penicillin-binding protein 1A gene called ponA. It was identified by RNAseq and the expression was validated by 5' and 3' RACE experiments in Pseudomanas aeruginosa. AsponA expression was up or down regulated under different antibiotic stress. Owing to its location it may be able to prevent the transcription or translation of the opposite gene.[1] Study by Wurtzel et al. and Ferrara et al. also detected its expression.[2][3]
See also
References
- ^ Gómez-Lozano M, Marvig RL, Tulstrup MV, Molin S (September 2014). "Expression of antisense small RNAs in response to stress in Pseudomonas aeruginosa". BMC Genomics. 15 (1): 783. doi:10.1186/1471-2164-15-783. PMC 4180829. PMID 25213728.
- ^ Wurtzel O, Yoder-Himes DR, Han K, Dandekar AA, Edelheit S, Greenberg EP, Sorek R, Lory S (September 2012). "The single-nucleotide resolution transcriptome of Pseudomonas aeruginosa grown in body temperature". PLOS Pathogens. 8 (9): e1002945. doi:10.1371/journal.ppat.1002945. PMC 3460626. PMID 23028334.
- ^ Ferrara S, Brugnoli M, De Bonis A, Righetti F, Delvillani F, Dehò G, Horner D, Briani F, Bertoni G (2012). "Comparative profiling of Pseudomonas aeruginosa strains reveals differential expression of novel unique and conserved small RNAs". PLOS ONE. 7 (5): e36553. Bibcode:2012PLoSO...736553F. doi:10.1371/journal.pone.0036553. PMC 3349714. PMID 22590564.